PDF(Pubmed)
Abstract：
This report describes a case involving the diagnosis and treatment of squamous cell carcinoma (SCC) of the duodenum, which was found to be a metastatic lesion originating from recurrent head and neck cancer (HNC) in a 74-year-old female patient. The patient had a past medical history of gastroesophageal reflux disease (GERD), tonsillar SCC, and recurrent HNC. She presented with symptoms of burning, tingling, and numbness of the throat and left side of the tongue. Upon examination with an esophagogastroduodenoscopy, an ulcerated hard area mass was detected in the third portion of the duodenum. Biopsy results confirmed the mass to be a metastatic poorly differentiated SCC. The incidence of head and neck squamous cell carcinoma (HNSCC) metastasis to the duodenum is rare, likely due to the unique anatomic location and the lack of lymphatic drainage in the area. The patient was treated with a combination of paclitaxel, carboplatin, and pembrolizumab. This case underscores the significance of considering unusual sites of metastasis in HNSCC patients and utilizing advanced imaging modalities and immunotherapy to detect and treat these locations effectively.
摘要：
本报告描述了一例涉及十二指肠鳞状细胞癌（SCC）的诊断和治疗的病例，在一名74岁的女性患者中，发现这是源于复发性头颈部癌（HNC）的转移性病变。患者有胃食管反流病（GERD）的既往病史，扁桃体SCC,和复发性HNC。她出现了灼烧的症状,刺痛,喉咙和舌头左侧麻木。经食管胃十二指肠镜检查，在十二指肠的第三部分检测到溃疡硬区肿块。活检结果证实该肿块是转移性低分化SCC。头颈部鳞状细胞癌（HNSCC）向十二指肠转移的发生率很少，可能是由于该地区独特的解剖位置和缺乏淋巴引流。患者接受了紫杉醇的联合治疗，卡铂,和Pembrolizumab.此病例强调了考虑HNSCC患者异常转移部位并利用先进的成像方式和免疫疗法有效检测和治疗这些部位的重要性。
