METHODS: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC. We investigated complication rate, survival outcomes (Overall Survival, Disease Specific Survival, Loco-Regional Recurrence Free Survival) and functional outcomes (tracheal tube and/or gastrostomy dependence).
RESULTS: Sixty-one patients were included in the analysis. No major complications or perioperative deaths were recorded. The estimated 2-year OS was 76.7%, DSS 81.8% and LRRFS 50.5%. In multivariable analysis rpT, PNI (perineural infiltration) and HPV-positivity were significantly associated with LRRFS (Hazard Ratios: T3 vs T1 6.43, PNI yes vs no 4.19, HPV+ yes vs no 2.63). At last follow up, 97% of patients were tracheal tube-free, while 93% were gastrostomy-free.
CONCLUSIONS: Transoral robotic salvage surgery is a successful treatment in selected patients affected by rOPSCC because it grants good oncologic and functional outcomes.
方法:我们对行cT1-3rOPSCC颈清扫术或无颈清扫术的患者进行了单中心回顾性分析。我们调查了并发症发生率,生存结果(总生存率,疾病特异性生存率,本地区域复发无生存)和功能结果(气管导管和/或胃造口术依赖)。
结果:61例患者纳入分析。无重大并发症或围手术期死亡记录。估计2年OS为76.7%,DSS81.8%和LRRFS50.5%。在多变量分析rpT中,PNI(神经周浸润)和HPV阳性与LRFS显着相关(危害比:T3vsT16.43,PNI是vs无4.19,HPV是vs无2.63)。最后跟进,97%的患者无气管导管,而93%的患者无胃造口术。
结论:经口机器人抢救手术是对受rOPSCC影响的特定患者的成功治疗,因为它具有良好的肿瘤学和功能预后。