背景:COVID-19后综合征最常见的身体成分改变包括肌肉质量低,强直症,少肌症,和肥胖。这些疾病共有相互关联的病理生理机制,彼此恶化。COVID-19后综合征的身体成分表型与代谢异常之间的关系尚不清楚。
目的:评估COVID-19后综合征非糖尿病个体的身体成分表型与胰岛素抵抗(IR)和代谢异常之间的关系。
方法:横截面,单中心研究涉及483名需要住院治疗的中度至重度急性COVID-19后COVID-19综合征受试者。糖尿病患者,那些拒绝参加的人,或者无法联系的人被排除在外。身体成分表型被归类为正常体重,强直症,少肌症,肥胖,和肌少症性肥胖(SO)。
结果:平均年龄为52.69±14.75岁;值得注意的是,67.08%为男性。体成分表型的患病率如下:13.25%为正常体重,9.52%的人患有强迫症,9.94%患有肌少症,43.69%有肥胖,18.84%的人患有发育不良性肥胖,4.76%有SO。此外,58.18%有IR。肥胖(OR:2.98,CI95%;1.64-5.41)和发育不良性肥胖(OR:4.98,CI95%;1.46-6.88)与IR相关。
结论:最常见的身体成分表型是肥胖,肥胖,和强迫症。此外,肥胖和肥胖障碍与COVID-19后综合征的IR相关。
BACKGROUND: The most frequent body composition alterations in post-COVID-19 syndrome include low muscle mass, dynapenia, sarcopenia, and obesity. These conditions share interconnected pathophysiological mechanisms that exacerbate each other. The relationship between body composition phenotypes and metabolic abnormalities in post-COVID-19 syndrome remains unclear.
OBJECTIVE: To evaluate the association between body composition phenotypes and insulin resistance (IR) and metabolic abnormalities in non-diabetic individuals with post-COVID-19 syndrome.
METHODS: A cross-sectional, single-center study involving 483 subjects with post-COVID-19 syndrome following moderate to severe acute COVID-19 requiring hospitalization. Individuals with diabetes, those who declined to participate, or those who could not be contacted were excluded. Body composition phenotypes were classified as normal weight, dynapenia, sarcopenia, dynapenic obesity, and sarcopenic obesity (SO).
RESULTS: The average age was 52.69 ± 14.75 years; of note, 67.08% were male. The prevalence of body composition phenotypes was as follows: 13.25% were of normal weight, 9.52% had dynapenia, 9.94% had sarcopenia, 43.69% had obesity, 18.84% had dynapenic obesity, and 4.76% had SO. Additionally, 58.18% had IR. Obesity (OR: 2.98, CI95%; 1.64-5.41) and dynapenic obesity (OR: 4.98, CI95%; 1.46-6.88) were associated with IR.
CONCLUSIONS: The most common body composition phenotypes were obesity, dynapenic obesity, and dynapenia. Furthermore, obesity and dynapenic obesity were associated with IR in post-COVID-19 syndrome.