背景:慢性光敏性皮炎(CPD)(也称为光化性网状蛋白)是一种罕见的疾病,通常在老年男性中提及。受影响的患者严重瘙痒,多年来暴露在阳光下的干性皮肤变厚。
方法:一名高加索女性患者,她的大部分时间都在外面工作,脖子上有“慢性皮炎”,她在阳光明媚的日子开始在她的花园里种植菊花。稍后,她出现了水肿,红斑,丘疹,脖子上有几个囊泡严重瘙痒.
方法:皮肤活检显示诊断为CPD,随着紫外线B(UVB)的积极测试,UVB(MEDB)UVA(MEDA)和PhotoPath的最小红斑剂量(MED)。
结果:使用抗人纤维蛋白原抗体的直接免疫荧光(DIF)染色,白蛋白,IgG,IgM,lambda,kappa,真皮表皮连接处基膜区C3c和C1q呈阳性,在乳头状真皮中,以及所有真皮和细胞外基质中的神经血管束,尤其是那些在水泡下的。
结论:在这种情况下,我们建议不要忘记在重新激活的CPD病例中使用DIF以及照片补丁测试的重要性.
Chronic photosensitivity dermatitis (CPD) (also named actinic reticuloid) is an unusual disease classically referred often in elderly men. Affected patients have severely itchy, thickened dry skin in areas exposed to the sun throughout the years.
A Caucasian female patient who worked most of her life outside who had \"chronic dermatitis\" in her neck started planting chrysanthemum in her garden on a sunny day. Later, she presented edema, erythema, papules, and a few vesicles in her neck with severe pruritus.
A skin biopsy revealed the diagnosis of CPD, along with positive testing for ultraviolet B (UVB), minimal erythema doses (MED) for UVB (MEDB) UVA (MEDA) and PhotoPath.
Direct immunofluorescence (DIF) stains using anti-human antibodies against fibrinogen, albumin, IgG, IgM, lambda, kappa, and C3c and C1q were positive at the base membrane area of the dermal epidermal junction, in the papillary dermis, as well as the neurovascular bundles in all the dermis and the extracellular matrix, especially those under the blisters.
With this case, we suggest not forgetting the importance of using DIF in reactivated CPD cases in addition to the photo patch testing.