performance anxiety

  • 文章类型: Journal Article
    目的:这项研究旨在研究肌肉骨骼疾病发作(MDE)的发生率与整个舞蹈季节的强迫性和和谐的激情以及表现焦虑之间的关系。持续了38周。
    方法:前瞻性队列研究。
    方法:总共招募了118名专业和职业前舞者,并在基线时进行了评估,88完成了后续工作。在舞蹈季开始时,使用激情量表和肯尼音乐表演焦虑量表评估了他们的激情和表演焦虑水平,分别。为了监测整个舞蹈季节的多氯联苯发生率,舞者被要求完成每周的电子日记。
    结果:更高的强迫激情水平与导致舞蹈活动中断的MDE发生率更高相关(β=0.264,p=0.022)。在整个赛季中,和谐的激情和表现焦虑与MDE无关。
    结论:这项研究的结果支持了强迫性激情在舞蹈演员发展中的作用。
    This study aimed to examine the association between the incidence of musculoskeletal disorder episodes (MDEs) and obsessive and harmonious passion as well as performance anxiety throughout a dance season, which lasted 38 weeks.
    Prospective cohort study.
    A total of 118 professional and preprofessional dancers were recruited and assessed at baseline, while 88 completed the follow-up. Their levels of passion and performance anxiety were assessed at the beginning of a dance season using the Passion Scale and the Kenny Music Performance Anxiety Inventory, respectively. To monitor the incidence of MDEs throughout a dance season, dancers were asked to complete a weekly electronic diary.
    A higher level of obsessive passion was associated with a higher incidence of MDEs causing an interruption of dance activities (β = 0.264, p = 0.022). Harmonious passion and performance anxiety were not associated with MDEs throughout the season.
    Findings of this study support the role of obsessive passion in the development of MDEs in dancers.
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  • 文章类型: Journal Article
    神经内分泌系统对人类之间的隶属行为具有重要意义,可用于评估社会关系之间的相关性,压力,和健康。这可能受到社会亲密关系的影响;这方面是与另一个人或一群人(例如运动队)的亲密关系。运动表现焦虑被认为是一种由生理、认知,情感,和行为成分。这促使我们了解可能影响竞争结果的过程。激素和遗传学似乎会影响结果和表现。在这方面,许多研究都集中在运动反应作为卵巢激素的功能,并已观察到,孕激素是一种在减少焦虑中起关键作用的激素,因此压力,在人类和其他动物中。另一方面,众所周知,高皮质醇浓度会导致焦虑水平增加。然而,唾液α-淀粉酶(sAA)酶被认为是急性应激的标志,而不是皮质醇。在脑源性神经营养因子(BDNF)和纹状体多巴胺转运蛋白(DAT)的情况下,遗传学似乎也会影响焦虑和压力管理。因此,这项研究旨在调查社会亲密关系,作为衡量运动队凝聚力的指标,可以影响运动员的表现结果,以及它影响荷尔蒙分泌的能力,比如孕酮和皮质醇,这影响了运动焦虑的管理,同时也考虑了排球比赛期间的遗传背景。
    自愿参加本研究的26名女子排球运动员(平均值±SD:年龄,12.07±0.7年),并参加了巴勒莫省排球锦标赛的决赛。所有女孩都在卵巢周期,详细说明在卵泡期和排卵早期之间。
    结果显示,仅在获胜组中唾液皮质醇显着下降(p<0.039)。事实上,而在后者中,赛前水平为7.7ng/ml,赛后降至4.5ng/ml,失败者组的变化无统计学意义(7.8ng/mlvs6.6ng/ml赛前和赛后).关于sAA浓度,获胜团队在比赛前和比赛后的差异具有统计学意义(166.01±250U/mlvs291.59±241U/ml)(p=0.01)。
    分析SAS-2心理测验的结果,平均而言,失败者比胜利者更焦虑,这有助于最终的结果。总之,有强有力的证据表明,许多因素可以影响表演焦虑,从而影响表演本身。
    UNASSIGNED: The neuroendocrine system has important implications for affiliation behavior among humans and can be used to assess the correlation between social relationships, stress, and health. This can be influenced by social closeness; this aspect is the closeness towards another individual or a group of individuals such as a sports team. Sports performance anxiety is considered an unpleasant emotional reaction composed of physiological, cognitive, affective, and behavioral components. This motivates us to learn about the process that can influence the outcome of competition. Hormones and genetics would seem to influence outcome and performance. In this regard, many studies have focused on the exercise response as a function of ovarian hormones and it has been observed that progesterone is a hormone that plays a key role in reducing anxiety, and thus stress, in humans and other animals. On the other hand, high cortisol concentrations are known to contribute to increased anxiety levels. However, the salivary alpha-amylase (sAA) enzyme has been suggested as marker of acute stress than cortisol. Genetics also seem to influence anxiety and stress management as in the case of brain-derived neurotrophic factor (BDNF) and striatal dopamine transporter (DAT). Therefore, the study aims to investigate social closeness, as a measure of sports team cohesion that can influence athletes\' performance results, and its ability to influence the secretion of hormones, such as progesterone and cortisol, that affect the management of sports anxiety while also taking into account genetic background during a volleyball match.
    UNASSIGNED: Twenty-six female volleyball players who volunteered participated in this study (mean ± SD: age, 12.07 ± 0.7 years), and played in the final of the provincial volleyball championship in Palermo. All girls were during the ovarian cycle, in detail between the follicular and early ovulatory phases.
    UNASSIGNED: The results showed a significant decrease in salivary cortisol only in the winning group (p < 0.039). In fact, whilst in the latter the pre-match level was 7.7 ng/ml and then decreased to 4.5 ng/ml after the match, in the losers group change was not statistically significant (7.8 ng/ml vs 6.6 ng/ml pre- and post-match). As to the sAA concentration, the winning team showed a statistically significant variation between pre- and post-match than the losers (166.01 ± 250 U/ml vs 291.59 ± 241 U/ml) (p = 0.01).
    UNASSIGNED: Analyzing the results of the SAS-2 psychological test it is highlighted that, on average, the loser group was more anxious than the winning group, and this contributed to the final result. In conclusion, there is strong evidence supporting the state of the art that many factors can affect performance anxiety and thus the performance itself.
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  • 文章类型: English Abstract
    目的:开发一种测量工具,用于医生在产科手术期间的表现焦虑,作为一份自我管理的问卷。
    方法:我们使用德尔菲法。首先,我们进行了文献综述,以确定第一轮提交的项目.要求一个专家小组对项目的相关性进行从1到6的评级。对于Delphi的第一轮,如果超过70%的受访者给予5或6个评级,则项目被保留。如果超过70%的受访者给出了一个或两个评级,则项目被排除在外。所有其他项目,加上小组建议的,被提交给第二轮德尔福。将相同的项目选择条件应用于第二轮。
    结果:对Delphi的总体反应率为79%(19名受访者)。在第一轮结束时,14个项目是自愿相关的,没有一项是自愿无关的。对于第二轮,提交了第一轮专家建议的18个项目和7个新项目。在第二轮结束时,九个项目以协商一致方式保留。
    结论:这项研究通过共识定义了23项自我问卷来衡量产科的具体表现焦虑,分为五个维度:感知压力,评估并发症的风险,医疗法律风险,医疗团队和同行的影响,自信和决策自信。我们打算在实际人口中验证此工具。
    OBJECTIVE: Developing a measuring tool for physician\'s performance anxiety during obstetrical procedures, as a self-administered questionnaire.
    METHODS: We used the Delphi method. First, we did a literature review to identify the items to submit for the first round. A panel of experts was asked to rate the relevance of items from one to six. For the first round of Delphi, items were retained if more than 70% of respondents assigned a five or six rating. Items were excluded if more than 70% of respondents assigned a one or two rating. All the other items, plus those suggested by the panel, were submitted to a second round of Delphi. The same item selection conditions were applied to the second round.
    RESULTS: The overall response rate to the Delphi was 79% (19 respondents). At the end of the first round, 14 items were consensually relevant, no item was consensually irrelevant. For the second round, the 18 items that did not find consensus and seven new items suggested by the experts in the first round were submitted. At the end of the second round, nine items were retained by consensus as relevant.
    CONCLUSIONS: This study defined by consensus 23 items for a self-questionnaire to measure specific performance anxiety in obstetrics divided into five dimensions: perceived stress, assessment of the risk of complications, medico-legal risk, impact of the healthcare team and peers, self-confidence and decision-making confidence. We intend to validate this tool in real population.
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  • 文章类型: Journal Article
    亚阈值社交焦虑(SSA)是个人经历社交焦虑的一种状况,该状况未达到社交焦虑症(SAD)的临床诊断所需的阈值。尽管SSA可能不会像SAD那样严重损害生命,它会影响社会功能。然而,只有少数研究集中在SSA的结构神经相关性上。我们招募了65名SSA患者,并使用Leibowitz社交焦虑量表评估他们的社交和表现焦虑水平以及其他相关社交焦虑指标。体素全脑相关分析显示,额上回(SFG)的皮质厚度(CT)与社交焦虑水平之间呈正相关,而梭状回(FG)的CT与表现焦虑水平之间呈负相关。SSA个体。探索性Pearson的相关性分析显示,SFG的CT与广泛性焦虑症-7总分之间存在显着正相关,而FG的CT与贝克焦虑量表总分之间存在负相关。我们的研究提供了对SSA的神经基础的见解,尤其是表现焦虑,通过强调特定大脑区域的CT和SSA特征之间的关联。
    Subthreshold social anxiety (SSA) is a condition in which individuals experience social anxiety that does not reach the threshold required for a clinical diagnosis of a social anxiety disorder (SAD). Although SSA may not impair lives as severely as SAD, it can affect social functioning. However, only a few studies focused on structural neural correlates of SSA. We recruited 65 individuals with SSA and used the Leibowitz Social Anxiety Scale to assess their social and performance anxiety levels and other relevant measures of social anxiety. Voxel-wise whole-brain correlational analyses showed a positive association between the cortical thickness (CT) of the superior frontal gyrus (SFG) and social anxiety levels and a negative correlation between the CT of the fusiform gyrus (FG) and performance anxiety levels in individuals with SSA. Exploratory Pearson\'s correlation analyses showed significant positive correlations between the CT of the SFG and Generalized Anxiety Disorder-7 total scores and negative associations between the CT of the FG and Beck Anxiety Inventory total scores. Our study provides insight into the neural basis of SSA, particularly performance anxiety, by highlighting the association between CT in specific brain regions and SSA characteristics.
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  • 文章类型: Journal Article
    背景:未完成婚姻(UCM)是异性恋已婚夫妇无法进行阴道性交。
    目的:本研究旨在系统回顾目前关于UCM病因和临床治疗的证据。
    方法:在MEDLINE上进行全面的书目搜索,Scopus,WebofScience,Cochrane图书馆数据库于2023年6月进行。如果他们在病例报告或病例系列中描述了从未发生过性交的已婚夫妇,则选择研究以定性评估相关原因和/或管理和报告数据,定量,或混合方法。根据PRISMA(系统评价和荟萃分析的首选报告项目)声明报告,并在PROSPERO中注册,ID为CRD42023433040。
    结果:共27项研究,包括1638名男性和1587名女性。8篇(29.6%)文章是涉及一对夫妇的病例报告,19篇(70.4%)研究是病例系列。平均Murad评分为4.1(范围,1-8)显示低中间的整体研究质量。所有文章的证据水平均为4。大多数研究在埃及进行(n=5[18.4%]),以色列(n=4[14.9%]),和美国(n=4[14.9%])。男性和女性的平均年龄在24.2至37.6岁和21至27.4岁之间变化,分别。导致UCM诊断的医疗访问的原因是在23项(85.2%)研究中无法完善,无法在一篇(3.7%)文章中怀孕,并混合在3(11.1%)个物品中。UCM的平均持续时间从7天到3.5年不等。涉及男性和女性的八项研究表明,阴道痉挛(8.4%-81%)和勃起功能障碍(10.5%-61%)是UCM的最常见原因。三篇文章报道,所有UCM病例中有16.6%至26%是由于男性和女性因素造成的。西地那非,他达拉非,海绵体内注射,阴茎折叠术,女性生殖器重建手术,阴道扩张器,润滑剂性心理治疗,在27项研究中,性教育是各种治疗方式,完成率为66.6%至100%。
    一个优点是,这是第一个涵盖UCM整个范围的系统综述。局限性包括大多数纳入的文章的质量低,以及可能未发表的大部分UCM案例。
    结论:勃起功能障碍和阴道痉挛是UCM报道最多的原因;然而,强大的心理因素无疑是许多案件的基础。基于性教育战略整合的多学科方法,医学治疗,性心理支持,手术治疗似乎是管理UCM夫妇的最合适选择。
    BACKGROUND: Unconsummated marriage (UCM) is the inability of the heterosexual married couple to have penovaginal sexual intercourse.
    OBJECTIVE: The study sought to systematically review current evidence regarding the etiological factors and clinical management of UCM.
    METHODS: A comprehensive bibliographic search on the MEDLINE, Scopus, Web of Science, and Cochrane Library databases was performed in June 2023. Studies were selected if they described married couples who never had sexual intercourse in case report or case series evaluating the related causes and/or management and reporting data with qualitative, quantitative, or mixed methods. The review was reported according to PRISMA (Preferred Reporting Items for Systematic Review and Meta-analyses) statement and registered in PROSPERO with ID CRD42023433040.
    RESULTS: A total of 27 studies including 1638 males and 1587 females were selected. Eight (29.6%) articles were case reports involving a single couple and 19 (70.4%) studies were case series. Mean Murad score was 4.1 (range, 1-8) showing low-intermediate overall study quality. All articles had a level of evidence of 4. Most of studies were conducted in Egypt (n = 5 [18.4%]), Israel (n = 4 [14.9%]), and the United States (n = 4 [14.9%]). The mean age of males and females varied between 24.2 and 37.6 years and from 21 to 27.4 years, respectively. The reasons for the medical visit that led to the diagnosis of UCM were inability to consummate in 23 (85.2%) studies, inability to conceive in 1 (3.7%) article, and mixed in 3 (11.1%) articles. The mean duration of UCM varied from 7 days to 3.5 years. Eight studies involving both men and women showed that vaginismus (8.4%-81%) and erectile dysfunction (10.5%-61%) were the most common causes of UCM. Three articles reported that 16.6% to 26% of all UCM cases were due to both male and female factors. Sildenafil, tadalafil, intracavernosal injection, penile plication, female genital reconstructive surgery, vaginal dilators, lubricants, psychosexual therapy, and sex education were the various treatment modalities in 27 studies to achieve consummation rate of 66.6% to 100%.
    UNASSIGNED: A strength is that this is the first systematic review covering the entire spectrum of UCM. Limitations comprised the low quality of most of the included articles and the large percentage of UCM cases probably not published.
    CONCLUSIONS: Erectile dysfunction and vaginismus are the most reported causes of UCM; however, a strong psychological component certainly underlies a significant number of cases. A multidisciplinary approach based on strategic integration of sex education, medical therapy, psychosexual support, and surgical treatment would seem the most suitable option to manage couples with UCM.
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  • 文章类型: Journal Article
    运动员和非运动员经历许多焦虑相关的症状和障碍在相当的比率。促成因素可能包括执行压力,公众监督,体育事业的不满,损伤,运动中的骚扰和虐待。焦虑可能会对运动表现产生负面影响。特定类型的焦虑可能在运动员中有独特的表现。重要的是排除焦虑症状的一般医学和物质相关原因。应考虑心理治疗和药物治疗方案,铭记运动员的环境状况和生理。
    Athletes and non-athletes experience many anxiety-related symptoms and disorders at comparable rates. Contributory factors may include pressure to perform, public scrutiny, sporting career dissatisfaction, injury, and harassment and abuse in sport. Anxiety may negatively impact sport performance. Specific types of anxiety may have unique presentations in athletes. It is important to rule out general medical and substance-related causes of anxiety symptoms. Psychotherapy and pharmacology treatment options should be considered, bearing in mind athletes\' environmental circumstances and physiologies.
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  • 文章类型: Journal Article
    音乐表演焦虑(MPA)是一种自然,情感,以及对公共表演压力的生理反应。使MPA衰弱的形式是严重而持久的反应,超出了对音乐评估情况的正常适应性反应,并且会对音乐表演的质量和音乐家的生活产生负面影响。今天,它会影响许多专业表演者,并可能导致无法实践自己的专业,对他们的职业活动构成重大威胁。尽管它的范围,探索这一问题并有助于解决这一问题的研究很少。因此,这篇综述旨在从科学的角度汇编过去五年(2018-2023年)在MPA治疗方面取得的重大进展.为此,PRISMA方法是根据从WebofScience获得的结果使用的,Scopus,和谷歌学者数据库。审查了10项研究,这些研究在使用PRISMA方法应用质量过滤器后,在此时间范围内对此事做出了有价值的贡献。结论是,尽管目前的研究存在方法论上的缺陷和样本限制,这个领域注册进步,提供有价值的信息,以防止或解决这个问题,在专业或有抱负的音乐家。
    Music performance anxiety (MPA) is a natural, emotional, and physiological response to the stress of public performance. Debilitating forms of MPA are severe and persistent reactions that go beyond the normal adaptive response to music evaluation situations and can negatively impact the quality of musical performance and the musician\'s life in general. Today, it affects numerous professional performers and can result in an inability to practice their profession, posing a significant threat to their professional activity. Despite its scope, studies exploring this issue and contributing to its resolution are scarce. Thus, this review aims to compile the significant advancements made in the last five years (2018-2023) in the treatment of MPA from a scientific perspective. For this purpose, the PRISMA method was used based on the results obtained from the Web of Science, Scopus, and Google Scholar databases. Reviewed are 10 studies that have made valuable contributions to this matter in this time frame after applying the quality filters using the PRISMA method. It is concluded that, although there are methodological shortcomings and sample limitations in the current research, this field registers advancements that provide valuable information to prevent or solve this problem in professional or aspiring musicians.
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  • 文章类型: Journal Article
    背景:研究表明,数学焦虑与小学数学成绩呈负相关,包括分数知识。然而,最近,分数运算性能与分数任务后测量的状态焦虑之间没有发现显着相关性。一种可能的解释是自然数偏差(NNB),在分数任务中应用自然数推理的趋势,即使这是不合适的。NNB的学生可能没有意识到他们的回答不正确。
    目的:目的是检查是否存在误解,即NNB,会影响学生的分数状态焦虑。
    方法:参与者是119名五年级和六年级学生,分为NNB组(n=60)或非NNB组(n=59)。根据他们在分数算术任务上与NNB相关的回答配置文件。
    方法:检查了小组差异的状态焦虑和分数和整数算术任务的表现以及自我报告的特质数学焦虑。
    结果:NNB组的分数状态焦虑低于非NNB组,但特质数学焦虑没有显著差异。此外,NNB组报告的分数状态焦虑低于整数状态焦虑,而No-NNB组则相反。
    结论:本研究表明,学生对自己表现的看法会影响他们的状态焦虑反应,NNB的学生可能没有意识到他们的误解和表现不佳。不考虑低性能的质的差异,比如误解,可能会导致对状态焦虑-表现关系的误解。
    BACKGROUND: Research has shown that mathematics anxiety negatively correlates with primary school mathematics performance, including fraction knowledge. However, recently no significant correlation was found between fraction arithmetic performance and state anxiety measured after the fraction task. One possible explanation is the natural number bias (NNB), a tendency to apply natural number reasoning in fraction tasks, even when this is inappropriate. Students with the NNB may not realize they are answering incorrectly.
    OBJECTIVE: The aim is to examine whether a misconception, namely the NNB, can influence students\' fraction state anxiety.
    METHODS: The participants were 119 fifth- and sixth-grade students categorized as belonging to an NNB group (n = 60) or a No-NNB group (n = 59), according to their NNB-related answering profile on a fraction arithmetic task.
    METHODS: Group differences were examined for state anxiety and performance on a fraction and a whole number arithmetic task and self-reported trait mathematics anxiety.
    RESULTS: The NNB group reported lower fraction state anxiety than the No-NNB group, but there was no significant difference in trait mathematics anxiety. Furthermore, the NNB group reported lower fraction state anxiety than whole number state anxiety, while the opposite was true for the No-NNB group.
    CONCLUSIONS: The present study suggests that students\' perceptions of their own performance influence their state anxiety responses, and students with a NNB may not be aware of their misconception and poor performance. Not taking into account qualitative differences in low performance, such as misconceptions, may lead to misinterpretations in state anxiety-performance relations.
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  • 文章类型: Journal Article
    表现焦虑是恐惧,焦虑,或避免执行任务,由于他人可能的评价或批评。表演焦虑在公共演讲者中得到了很好的描述,音乐家,甚至是外科医生.尚未探索其对放射科医师,尤其是放射学受训者的影响。这篇文章详细介绍了表演焦虑,将放射科医生装扮成表演者,并强调其对受训者和执业放射科医生的潜在影响。我们提供策略来管理和增强可以在培训环境中实施的绩效焦虑的影响。
    Performance anxiety is fear, anxiety, or avoidance of performative tasks, due to possible evaluation or criticism by others. Performance anxiety is well described in public speakers, musicians, and even surgeons. Its impact on radiologists and especially radiology trainees has not been explored. This article details performance anxiety, framing radiologists as performers, and highlights its potential impact on trainees and practicing radiologists. We offer strategies to manage and enhance the effects of performance anxiety that can be implemented in a training environment.
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  • 文章类型: Randomized Controlled Trial
    表演焦虑是专业音乐家中最常见的焦虑障碍。典型的症状是-在物理层面上-心脏压力引起的交感神经紧张增加的后果,比如心跳加速,血压升高,呼吸频率增加和震颤直至恶心或潮红反应。这些症状会导致情绪困扰,减少的音乐和艺术表现,直到功能受损。虽然焦虑症最好使用暴露的认知行为疗法来治疗,这种方法对于治疗音乐表演焦虑是相当困难的,因为需要公众或专业陪审团的存在,而且不容易获得。因此,使用虚拟现实(VR)可以显示另一种选择。到目前为止,没有应用虚拟现实暴露疗法对音乐表现焦虑的治疗研究调查了治疗结果,包括心血管变化作为结果参数.
    这个单中心,prospective,随机对照临床试验采用术后前设计,随访期为6个月.46名专业和半专业音乐家将被招募并随机分配到VR暴露组或接受渐进式肌肉放松训练的对照组。两组将在4个单独的会议治疗。音乐表演焦虑将根据使用ICD-10和DSM-5标准的特定恐惧症或社交焦虑的临床访谈进行诊断。行为评估测试进行三次(预,post,跟进)在VR中通过音乐厅的试镜。主要结果是由德国Bühnenangstfragebogen测量的音乐表现焦虑的变化以及由心率变异性(HRV)反映的心血管反应性。次要结果是血压的变化,压力参数,如血液和唾液中的皮质醇,神经肽,和DNA甲基化。
    该试验调查了与放松技术相比,VR暴露于演奏焦虑的音乐家对焦虑症状和相应心血管参数的影响。我们期望焦虑的减少,但HRV的连续改善具有心血管保护作用。
    这项研究已在临床试验中注册。(ClinicalTrials.gov编号:NCT05735860)。
    Performance anxiety is the most frequently reported anxiety disorder among professional musicians. Typical symptoms are - on a physical level - the consequences of an increase in sympathetic tone with cardiac stress, such as acceleration of heartbeat, increase in blood pressure, increased respiratory rate and tremor up to nausea or flush reactions. These symptoms can cause emotional distress, a reduced musical and artistical performance up to an impaired functioning. While anxiety disorders are preferably treated using cognitive-behavioral therapy with exposure, this approach is rather difficult for treating music performance anxiety since the presence of a public or professional jury is required and not easily available. The use of virtual reality (VR) could therefore display an alternative. So far, no therapy studies on music performance anxiety applying virtual reality exposure therapy have investigated the therapy outcome including cardiovascular changes as outcome parameters.
    This mono-center, prospective, randomized and controlled clinical trial has a pre-post design with a follow-up period of 6 months. 46 professional and semi-professional musicians will be recruited and allocated randomly to an VR exposure group or a control group receiving progressive muscle relaxation training. Both groups will be treated over 4 single sessions. Music performance anxiety will be diagnosed based on a clinical interview using ICD-10 and DSM-5 criteria for specific phobia or social anxiety. A behavioral assessment test is conducted three times (pre, post, follow-up) in VR through an audition in a concert hall. Primary outcomes are the changes in music performance anxiety measured by the German Bühnenangstfragebogen and the cardiovascular reactivity reflected by heart rate variability (HRV). Secondary outcomes are changes in blood pressure, stress parameters such as cortisol in the blood and saliva, neuropeptides, and DNA-methylation.
    The trial investigates the effect of VR exposure in musicians with performance anxiety compared to a relaxation technique on anxiety symptoms and corresponding cardiovascular parameters. We expect a reduction of anxiety but also a consecutive improvement of HRV with cardiovascular protective effects.
    This study was registered on clinicaltrials.gov. (ClinicalTrials.gov Number: NCT05735860).
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