目的:伽玛刀(GKRS)治疗眼眶海绵状血管瘤(OCH)的临床效果明显,并发症发生率低,已成为一种有前途的方法。本研究旨在评估GKRS治疗OCH的安全性和有效性。
方法:根据PRISMA框架,我们搜索了PubMed,CochraneCentral,和Embase用于报告OCHGKRS结果的研究。报告并发症的研究,视觉改善,突增,肿瘤减少率,包括GKRS后OCH的肿瘤进展率。
结果:六项研究,在1856个搜索结果中,包括100名患者。其中,只有5个轻微的并发症与GKRS有关,包括3例眼眶疼痛和2例眼眶周围放化疗。因此,并发症发生率为13%(95%CI,7-25%).GKRS后视力和视野改善率分别为80%(95%CI,63-96%)和71%(95%CI,47-95%)。94%的病例中,前突改善(95%CI,83-100%)。GKRS后肿瘤缩小率为77%(95%CI,69-85%)。
结论:用于OCH的GKRS似乎是一种安全的技术,临床改善率和放射学改善率证明了这一点。然而,研究受到对照组缺失的限制.与OCH的替代手术方式相比,还需要其他研究来评估GKRS的相对疗效。
OBJECTIVE: Gamma knife radiosurgery (GKRS) for orbital cavernous hemangioma (OCH) has emerged as a promising method due to its significant clinical improvement and low incidence of complications. This study aimed to evaluate the safety and efficacy of GKRS for the treatment of OCH.
METHODS: In accordance with the PRISMA framework, we searched PubMed, Cochrane Central, and Embase for studies reporting outcomes of GKRS for OCH. Studies reporting complications, visual improvement, proptosis, tumor reduction rate, and tumor progression rate for OCH following GKRS were included.
RESULTS: Six studies, out of 1856 search results, with 100 patients were included. Among them, only 5 minor complications were related to GKRS, including 3 with orbital pain and 2 with periorbital chemosis. Thus, the complication rate was 13% (95% CI, 7-25%). Visual acuity and visual field improvement rates after GKRS were 80% (95% CI, 63-96%) and 71% (95% CI, 47-95%) respectively. Proptosis improved in 94% of cases (95% CI, 83-100%). The tumor reduction rate was 77% after GKRS (95% CI, 69-85%).
CONCLUSIONS: GKRS for OCH appears to be a safe technique, as evidenced by the rate of clinical improvement and radiological improvement. However, studies are limited by an absence of a control group. Additional studies are needed to evaluate the relative efficacy of GKRS as compared with alternative surgical modalities for OCH.