背景:带电极-骨骼肌电刺激(B-SES)是一种针对难以进行运动疗法以改善肌肉力量的个体的治疗方法,运动耐受力,和葡萄糖代谢。然而,尚未研究B-SES对中央和下肢导管动脉血流动力学的影响。因此,这项研究比较了B-SES对健康年轻男性的中央和下肢动脉的急性影响。
方法:这项随机交叉研究包括9名健康年轻男性(平均年龄:21.0±1.1岁)。参与者被分配到以下实验条件,冲洗期为一周:条件1包括在参与者的感觉阈值强度下对下肢进行20分钟的电刺激(假,n=9),条件2包括以参与者可以忍受的最大强度对下肢进行20分钟的电刺激(B-SES,n=9)。心率(HR),每搏输出量(SV),心输出量(CO),平均动脉压(MAP),和总外周血管阻力(TPR)测量为中心血流动力学。测量并计算下肢导管动脉的血流动力学,用于浅股动脉(SFA),包括血管直径,平均血流速度(MBFV),剪切速率(SR),和平均血流量(MBF)率。这些指标是在刺激前测量的(Pre),刺激(刺激)开始后10分钟,并在刺激结束后立即(后)。使用重复的双向方差分析比较这些指数。
结果:在B-SES中,HR(前:63.2±8.6;刺激:73.7±6.9;后:70.0±4.2bpm,p<0.01),CO(前:5.1±1.0;刺激:6.5±1.5,p<0.01;后:6.3±1.2L/min,p=0.02),和MAP(前:104.0±11.5;刺激:116.4±10.8,p<0.01;后:109.6±9.7mmHg,p=0.02)显著增加。此外,B-SES显着增加MBFV(前:19.2±4.0;刺激:50.5±14.9;后:30.1±4.0cm/s,p<0.01),SR(Pre:118.9±28.8;刺激:302.7±91。2,p<0.01;后:182.1±70.1/s,p=0.02),和MBF(前:382.0±61.5;刺激:1009.6±321.4;后:626.8±176.6mL/min,p<0.01)。然而,SV和TPR无显著变化.
结论:这项研究的结果表明,健康年轻男性的B-SES在不增加SV或TPR的情况下增加了CO,并改善了SFA中的MBFV和SR。
BACKGROUND: Belt electrode-skeletal muscle electrical stimulation (B-SES) is a treatment prescribed for individuals with difficulty performing exercise therapy that improves muscle strength, exercise tolerance, and glucose metabolism. However, the effects of B-SES on the hemodynamics of the central and lower extremity conduit arteries have not been studied. Therefore, this study compared the acute effects of B-SES on the central and lower extremity conduit arteries in healthy young males.
METHODS: This randomized crossover study included nine healthy young males (mean age: 21.0±1.1 years). Participants were assigned to the following experimental conditions, with a washout period of one week: condition 1 included 20 min of electrical stimulation of the lower extremity at the participant\'s sensation threshold intensity (Sham, n=9) and condition 2 included 20 min of electrical stimulation of the lower extremity at the maximum intensity the participant can tolerate (B-SES, n=9). The heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure (MAP), and total peripheral vascular resistance (TPR) were measured as central hemodynamics. The hemodynamics of the lower extremity conduit arteries were measured and calculated for the shallow femoral artery (SFA), including vessel diameter, mean blood flow velocity (MBFV), shear rate (SR), and mean blood flow (MBF) rate. These indices were measured before stimulation (Pre), 10 min after the start of stimulation (Stimulating), and immediately after the end of stimulation (Post). These indices were compared using a repeated two-way analysis of variance.
RESULTS: In B-SES, HR (Pre: 63.2±8.6; Stimulating: 73.7±6.9; Post: 70.0±4.2 bpm, p<0.01), CO (Pre: 5.1±1.0; Stimulating: 6.5±1.5, p<0.01; Post: 6.3±1.2 L/min, p=0.02), and MAP (Pre: 104.0±11.5; Stimulating: 116.4±10.8, p<0.01; Post: 109.6±9.7 mmHg, p=0.02) increased significantly. In addition, B-SES significantly increased MBFV (Pre: 19.2±4.0; Stimulating: 50.5±14.9; Post: 30.1±4.0 cm/s, p<0.01), SR (Pre: 118.9±28.8; Stimulating: 302.7±91. 2, p<0.01; Post: 182.1±70.1/s, p=0.02), and MBF (Pre: 382.0±61.5; Stimulating: 1009.6±321.4; Post: 626.8±176.6 mL/min, p<0.01). However, there were no significant changes in SV and TPR.
CONCLUSIONS: The findings of this study indicate that B-SES in healthy young males increases CO without increasing SV or TPR and improves the MBFV and SR in the SFA.