Abstract：
OBJECTIVE: This study aims to fill the knowledge gap regarding the effects of high frequency facial neuromuscular electrical stimulation (fNMES) on facial aging, using a device equipped with CERTEC (Cell Energy Regeneration Technology) operating between 40 and 190 kHz.
METHODS: This prospective split-face study was conducted at Tokyo University Hospital between March and May 2023 with 24 healthy adult women aged 30-59. The intervention group used the fNMES device along with basic skin care on one side of the face, and basic skin care alone on the other side for 8 weeks. Evaluations included changes in skin wrinkles, sagging, and blood flow.
RESULTS: This study found significant improvements in skin elasticity and degree of wrinkles in the areas intervened with fNMES (p < 0.05, respectively). In addition, the intervention resulted in significant improvements in jawline angle (p < 0.01), submental volume (p < 0.05), cheek volume (p < 0.05), maximum nasolabial fold depth (p = 0.03), and total volume of the nasolabial folds (p = 0.03). The fNMES intervention also showed improvement in blood flow (p < 0.05). These improvements were also subjectively assessed by the participants in subject questionnaires at 8 weeks after the intervention (p < 0.05).
CONCLUSIONS: This study suggests that high frequency fNMES effectively improves facial skin elasticity, reduces wrinkles and sagging, promotes blood flow, and contributes to overall facial appearance rejuvenation. Although further studies are needed, high frequency fNMES appeared promising as a noninvasive anti-aging therapy.
METHODS: This prospective split-face study was conducted at Tokyo University Hospital between March and May 2023 with 24 healthy adult women aged 30-59. The intervention group used the fNMES device along with basic skin care on one side of the face, and basic skin care alone on the other side for 8 weeks. Evaluations included changes in skin wrinkles, sagging, and blood flow.
RESULTS: This study found significant improvements in skin elasticity and degree of wrinkles in the areas intervened with fNMES (p < 0.05, respectively). In addition, the intervention resulted in significant improvements in jawline angle (p < 0.01), submental volume (p < 0.05), cheek volume (p < 0.05), maximum nasolabial fold depth (p = 0.03), and total volume of the nasolabial folds (p = 0.03). The fNMES intervention also showed improvement in blood flow (p < 0.05). These improvements were also subjectively assessed by the participants in subject questionnaires at 8 weeks after the intervention (p < 0.05).
CONCLUSIONS: This study suggests that high frequency fNMES effectively improves facial skin elasticity, reduces wrinkles and sagging, promotes blood flow, and contributes to overall facial appearance rejuvenation. Although further studies are needed, high frequency fNMES appeared promising as a noninvasive anti-aging therapy.
摘要：
目的：本研究旨在填补有关高频面部神经肌肉电刺激（fNMES）对面部衰老的影响的知识空白，使用配备CERTEC（电池能量再生技术）的设备，工作在40和190kHz之间。
方法：这项前瞻性分脸研究于2023年3月至5月在东京大学医院进行，对24名30-59岁的健康成年女性进行了研究。干预组使用fNMES设备以及面部一侧的基本皮肤护理，和基本的皮肤护理单独在另一边8周。评估包括皮肤皱纹的变化，下垂，和血液流动。
结果：这项研究发现，fNMES干预区域的皮肤弹性和皱纹程度显着改善（分别为p<0.05）。此外,干预导致下颌线角度显著改善(p<0.01)，精神下体积（p<0.05），脸颊体积（p<0.05），最大鼻唇沟深度（p=0.03），和鼻唇沟总体积（p=0.03）。fNMES干预还显示血流改善(p<0.05)。干预后8周，参与者在受试者问卷中也主观评估了这些改善（p<0.05）。
结论：这项研究表明，高频fNMES有效改善面部皮肤弹性，减少皱纹和下垂，促进血液流动，并有助于整体面部外观恢复。虽然还需要进一步的研究,高频fNMES作为一种非侵入性抗衰老疗法似乎很有希望.
方法：这项前瞻性分脸研究于2023年3月至5月在东京大学医院进行，对24名30-59岁的健康成年女性进行了研究。干预组使用fNMES设备以及面部一侧的基本皮肤护理，和基本的皮肤护理单独在另一边8周。评估包括皮肤皱纹的变化，下垂，和血液流动。
结果：这项研究发现，fNMES干预区域的皮肤弹性和皱纹程度显着改善（分别为p<0.05）。此外,干预导致下颌线角度显著改善(p<0.01)，精神下体积（p<0.05），脸颊体积（p<0.05），最大鼻唇沟深度（p=0.03），和鼻唇沟总体积（p=0.03）。fNMES干预还显示血流改善(p<0.05)。干预后8周，参与者在受试者问卷中也主观评估了这些改善（p<0.05）。
结论：这项研究表明，高频fNMES有效改善面部皮肤弹性，减少皱纹和下垂，促进血液流动，并有助于整体面部外观恢复。虽然还需要进一步的研究,高频fNMES作为一种非侵入性抗衰老疗法似乎很有希望.
