PDF(Pubmed)
Abstract：
UNASSIGNED: A global public health problem, frailty is closely associated with poor prognosis after percutaneous coronary intervention (PCI) in older patients with acute myocardial infarction (AMI). Although exercise intervention is the most commonly used method to reverse and alleviate frailty, its application is restricted in patients with acute myocardial infarction following PCI due to cardiovascular instability and autonomic imbalance. Consequently, there is a need for a new practical intervention to address frailty syndrome in these patients.
UNASSIGNED: This study aimed to investigate the effect of neuromuscular electrical stimulation in frail older AMI patients post-PCI.
UNASSIGNED: A single-blind, randomized controlled trial was carried out in the Department of Cardiovascular Medicine from March to October 2023. A total of 100 eligible participants were randomly divided into two groups: experimental (n = 50) and control (n = 50) groups, respectively. Both groups received usual care. The experimental group underwent neuromuscular electrical stimulation (NMES) on bilateral quadriceps and gastrocnemius muscles for 30 minutes daily from day 1 to day 7 after surgery. The primary outcomes measured included the frailty score, lower limb muscle strength, and lower limb muscle quality. Secondary outcomes included the activities of daily living score, inflammatory markers, and length of hospital stay. All participants were included in an intention-to-treat analysis after the study ended.
UNASSIGNED: The frailty scores of the two groups exhibited a gradual decrease over time, and the scores of the experimental group were lower than those of the control group at 4 and 7 days after surgery (P<0.001). Concurrently, the lower limb muscle strength showed an increasing trend over the time in the experimental group and a decreasing trend in the control group, and the scores of the experimental group surpassed those of the control group (p<0.001). Moreover, a statistical difference was observed in the lower limb muscle mass across the groups after 7 days postoperatively compared with baseline on both sides (p<0.05).
UNASSIGNED: Neuromuscular electrical stimulation has the potential to enhance lower limb function and alleviate frailty in elderly patients with acute myocardial infarction after PCI. These findings introduce a novel intervention approach for frailty management in the elderly population.
UNASSIGNED: This study aimed to investigate the effect of neuromuscular electrical stimulation in frail older AMI patients post-PCI.
UNASSIGNED: A single-blind, randomized controlled trial was carried out in the Department of Cardiovascular Medicine from March to October 2023. A total of 100 eligible participants were randomly divided into two groups: experimental (n = 50) and control (n = 50) groups, respectively. Both groups received usual care. The experimental group underwent neuromuscular electrical stimulation (NMES) on bilateral quadriceps and gastrocnemius muscles for 30 minutes daily from day 1 to day 7 after surgery. The primary outcomes measured included the frailty score, lower limb muscle strength, and lower limb muscle quality. Secondary outcomes included the activities of daily living score, inflammatory markers, and length of hospital stay. All participants were included in an intention-to-treat analysis after the study ended.
UNASSIGNED: The frailty scores of the two groups exhibited a gradual decrease over time, and the scores of the experimental group were lower than those of the control group at 4 and 7 days after surgery (P<0.001). Concurrently, the lower limb muscle strength showed an increasing trend over the time in the experimental group and a decreasing trend in the control group, and the scores of the experimental group surpassed those of the control group (p<0.001). Moreover, a statistical difference was observed in the lower limb muscle mass across the groups after 7 days postoperatively compared with baseline on both sides (p<0.05).
UNASSIGNED: Neuromuscular electrical stimulation has the potential to enhance lower limb function and alleviate frailty in elderly patients with acute myocardial infarction after PCI. These findings introduce a novel intervention approach for frailty management in the elderly population.
摘要：
■全球公共卫生问题，老年急性心肌梗死（AMI）患者的虚弱与经皮冠状动脉介入治疗（PCI）术后不良预后密切相关。虽然运动干预是最常用的扭转和缓解虚弱的方法，由于心血管不稳定和自主神经失衡,其在PCI术后急性心肌梗死患者中的应用受到限制.因此,需要一种新的实际干预措施来解决这些患者的虚弱综合征.
■本研究旨在探讨神经肌肉电刺激对老年AMI患者PCI术后的影响。
■单盲，随机对照试验于2023年3月至10月在心血管内科进行.将100名符合条件的参与者随机分为两组：实验组（n=50）和对照组（n=50）。分别。两组均接受常规护理。实验组在手术后第1天至第7天每天对双侧股四头肌和腓肠肌进行神经肌肉电刺激（NMES）30分钟。测量的主要结果包括虚弱评分，下肢肌肉力量,和下肢肌肉质量。次要结果包括日常生活活动评分，炎症标志物，和住院时间。研究结束后，所有参与者都被纳入意向治疗分析。
■两组的虚弱评分随着时间的推移逐渐降低，术后4、7天实验组评分均低于对照组(P<0.001)。同时,实验组下肢肌力随时间呈递增趋势,对照组呈递减趋势,实验组得分优于对照组(p<0.001)。此外，术后7天,两组患者下肢肌肉质量与基线相比有统计学差异(p<0.05).
■神经肌肉电刺激具有增强老年急性心肌梗死PCI术后下肢功能和减轻虚弱的潜力。这些发现为老年人群的虚弱管理引入了一种新的干预方法。
■本研究旨在探讨神经肌肉电刺激对老年AMI患者PCI术后的影响。
■单盲，随机对照试验于2023年3月至10月在心血管内科进行.将100名符合条件的参与者随机分为两组：实验组（n=50）和对照组（n=50）。分别。两组均接受常规护理。实验组在手术后第1天至第7天每天对双侧股四头肌和腓肠肌进行神经肌肉电刺激（NMES）30分钟。测量的主要结果包括虚弱评分，下肢肌肉力量,和下肢肌肉质量。次要结果包括日常生活活动评分，炎症标志物，和住院时间。研究结束后，所有参与者都被纳入意向治疗分析。
■两组的虚弱评分随着时间的推移逐渐降低，术后4、7天实验组评分均低于对照组(P<0.001)。同时,实验组下肢肌力随时间呈递增趋势,对照组呈递减趋势,实验组得分优于对照组(p<0.001)。此外，术后7天,两组患者下肢肌肉质量与基线相比有统计学差异(p<0.05).
■神经肌肉电刺激具有增强老年急性心肌梗死PCI术后下肢功能和减轻虚弱的潜力。这些发现为老年人群的虚弱管理引入了一种新的干预方法。
