■中链脂肪酸(MCFA)和二十二碳六烯酸(DHA)可影响轻度认知障碍(MCI)的发生。β-羟基丁酸酯(BHB),线粒体DNA拷贝数(mtDNAcn)和线粒体DNA(mtDNA)缺失可能是它们的潜在机制。本研究旨在探讨MCFAs之间的关系,DHA和MCI,以及潜在的机制。
■本研究采用天津市老年人营养与认知(TENC)队列研究数据,在随访期间,120例患者被确定为新发MCI,通过1:1匹配的性别选择了120名没有MCI的个体,年龄,和教育水平作为对照组。采用条件logistic回归分析和中介效应分析探讨二者之间的关系。
■较高的血清辛酸水平(OR:0.633,95%CI:0.520,0.769),血清DHA水平较高(OR:0.962,95%CI:0.942,0.981),更多的mtDNAcn(OR:0.436,95%CI:0.240,0.794)与更低的MCI风险相关,而更多的mtDNA缺失与更高的MCI风险相关(OR:8.833,95%CI:3.909,19.960)。中介分析表明,BHB和mtDNAcn,在系列中,在辛酸和MCI风险之间的关系中具有中介作用,mtDNA缺失在DHA和MCI风险之间的关联中具有中介作用。
■较高的血清辛酸和DHA水平与较低的MCI风险相关。辛酸可以通过BHB影响MCI的发病率,然后线粒体功能,或者通过线粒体功能,或直接。血清DHA水平可通过线粒体功能影响MCI的发生,或直接。
UNASSIGNED: Medium-chain fatty acids (MCFAs) and docosahexaenoic acid (DHA) could affect the occurrence of mild cognitive impairment (MCI). β-hydroxybutyrate (BHB), mitochondrial DNA copy number (mtDNAcn) and mitochondrial DNA (mtDNA) deletions might be their potential mechanisms. This study aimed to explore the relationship between MCFAs, DHA and MCI, and potential mechanisms.
UNASSIGNED: This study used data from Tianjin Elderly Nutrition and Cognition (TENC) cohort study, 120 individuals were identified with new onset MCI during follow-up, 120 individuals without MCI were selected by 1:1 matching sex, age, and education levels as the control group from TENC. Conditional logistic regression analysis and mediation effect analysis were used to explore their relationship.
UNASSIGNED: Higher serum octanoic acid levels (OR: 0.633, 95% CI: 0.520, 0.769), higher serum DHA levels (OR: 0.962, 95% CI: 0.942, 0.981), and more mtDNAcn (OR: 0.436, 95% CI: 0.240, 0.794) were associated with lower MCI risk, while more mtDNA deletions was associated with higher MCI risk (OR: 8.833, 95% CI: 3.909, 19.960). Mediation analysis suggested that BHB and mtDNAcn, in series, have mediation roles in the association between octanoic acid and MCI risk, and mtDNA deletions have mediation roles in the association between DHA and MCI risk.
UNASSIGNED: Higher serum octanoic acid and DHA levels were associated with lower MCI risk. Octanoic acid could affect the incidence of MCI through BHB, then mitochondria function, or through mitochondria function, or directly. Serum DHA level could affect the incidence of MCI through mitochondria function, or directly.