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Abstract：
Gastric cancer (GC) survivors may be more likely to develop osteoporosis. However, few studies on the relationship between GC and osteoporosis have been conducted on large patient populations. We aimed to determine the incidence of osteoporosis and identify related factors by comparing patients with GC and matched controls using the Korean National Health Insurance Service-National Sample Cohort (KNHIS-NSC). This study included 9078 patients with GC and 36,312 controls (1:4 propensity score-matched for sex, age, residence, and income). The hazard ratio (HR) for osteoporosis was significantly greater for GC patients than for controls according to Charlson Comorbidity Index (CCI) score-adjusted models (adjusted HR = 1.13). Kaplan-Meier analysis revealed that the cumulative incidence of osteoporosis during the follow-up period commencing from the index date was significantly greater in GC patients than in the controls (p = 0.0087). A positive correlation of osteoporosis with GC was detected for those aged < 65 years, males, and those with CCI scores = 0. In conclusion, the study findings suggest that men with GC aged < 65 years may be at an increased risk for osteoporosis. Research into additional risk factors and the optimal timing of interventions are needed to prevent fractures and minimize bone loss in GC survivors.
摘要：
胃癌（GC）幸存者可能更容易发展为骨质疏松症。然而,关于GC与骨质疏松症之间关系的研究很少在大量患者人群中进行。我们旨在通过使用韩国国家健康保险服务-国家样本队列（KNHIS-NSC）将患者与GC和匹配的对照进行比较来确定骨质疏松症的发生率并确定相关因素。这项研究包括9078例GC患者和36,312例对照（1：4倾向评分匹配性别，年龄,residence,和收入）。根据Charlson合并症指数（CCI）评分调整模型（调整后的HR=1.13），GC患者骨质疏松症的风险比（HR）明显高于对照组。Kaplan-Meier分析显示，从索引日期开始的随访期间，GC患者的骨质疏松症累积发生率明显高于对照组（p=0.0087）。在年龄<65岁的人群中，骨质疏松与GC呈正相关。男性,和那些与CCI分数=0。总之,研究结果表明，年龄<65岁的GC男性患骨质疏松症的风险增加。需要研究其他风险因素和最佳干预时机，以预防骨折并最大程度地减少GC幸存者的骨丢失。
