PDF(Pubmed)
Abstract：
OPFRs are emerging environmental pollutants with reproductive and endocrine toxicity. This study aimed to examine the association between environmental exposure to OPFRs during early pregnancy and GDM. This nested case-control study was based on a birth cohort that was constructed at a maternal and child health hospital, including 74 cases of GDM among 512 pregnant women. The OPFRs, including TBP, TBEP, TCEP, TDCPP, TMCP, TOCP, and TPHP during 10-14 weeks of pregnancy were determined using GC-MS. The association between the OPFRs and GDM was assessed using WQS and BKMR models. The levels of OPFRs were significantly elevated in GDM patients (60) compared with the controls (90). The WQS analysis showed that mixtures of the OPFRs were significantly associated with GDM (OR 1.370, 95% CI 1.036-1.810, P = 0.027), and TBP, TPHP, and TMCP were the major contributors to the mixed exposure effect. In the BKMR model, individual exposure to TBP, TPHP, and TMCP, and the interaction of TMCP with TBP and TPHP were significantly associated with GDM. Environmental exposure to OPFRs is positively associated with GDM. These findings provide evidence for the adverse effects of OPFR exposure on the health of pregnant women.
摘要：
OPFRs是具有生殖和内分泌毒性的新兴环境污染物。本研究旨在研究妊娠早期OPFRs环境暴露与GDM之间的关系。这项巢式病例对照研究基于在妇幼保健医院建立的出生队列，512例孕妇中GDM74例。OPFR,包括TBP,TBEP,TCEP,TDCPP,TMCP,TOCP,使用GC-MS测定妊娠10-14周的TPHP。使用WQS和BKMR模型评估OPFRs和GDM之间的关联。与对照组(90)相比,GDM患者(60)的OPFRs水平显著升高。WQS分析表明，OPFRs的混合物与GDM显着相关（OR1.370，95％CI1.036-1.810，P=0.027），还有TBP,TPHP,和TMCP是混合暴露效应的主要贡献者。在BKMR模型中,个体暴露于TBP，TPHP,和TMCP,TMCP与TBP和TPHP的交互作用与GDM显著相关。OPFRs的环境暴露与GDM呈正相关。这些发现为OPFR暴露对孕妇健康的不利影响提供了证据。
