耳念珠菌是一种新兴的真菌病原体,在世界各地引起与医疗保健相关的感染和爆发,死亡率很高。它很容易定殖皮肤,nares,住院患者的呼吸道和泌尿道,这种定植可能导致易感患者的侵袭性念珠菌感染。然而,国际卫生当局没有推荐的C.auris非殖民化协议。本研究的目的是评估C.auris对常用合成和天然抗菌产品的敏感性,肉汤微量稀释测定。合成防腐剂,包括氯己定,聚维酮碘,和制霉菌素被证明对C.auris具有杀真菌性。在测试的天然防腐剂中,茶树油和麦卢卡油均对C.auris具有杀真菌性,浓度小于或等于1.25%(v/v)。在25%(v/v)浓度下,麦卢卡蜂蜜抑制C.auris。在测试的商业产品中,manuka沐浴露和漱口水对C.auris具有杀真菌作用,其浓度小于或等于所提供产品的0.39%(w/v)和6.25%(v/v),分别,而茶树沐浴露和MedihoneyTM伤口凝胶显示出抑制真菌的特性。总之,这项研究证明了茶树油的良好体外抗真菌功效,麦卢卡油,manuka蜂蜜,和含有这些活性成分的市售防腐产品。未来的研究有必要评估这些抗菌产品在临床环境中的有效性。
念珠菌是一种新兴的超级真菌,对全球公共卫生构成严重威胁。天然抗菌剂及其商业卫生产品的出色抗真菌功效为开发针对耳念珠菌的替代脱色方案提供了新的见解。
Candida auris is an emerging fungal pathogen responsible for healthcare-associated infections and outbreaks with high mortality around the world. It readily colonizes the skin, nares, respiratory and urinary tract of hospitalized patients, and such colonization may lead to invasive Candida infection in susceptible patients. However, there is no recommended decolonization protocol for C. auris by international health authorities. The aim of this study is to evaluate the susceptibility of C. auris to commonly used synthetic and
natural antiseptic products using an in vitro, broth microdilution assay. Synthetic antiseptics including chlorhexidine, povidone-iodine, and nystatin were shown to be fungicidal against C. auris. Among the
natural antiseptics tested, tea tree oil and manuka oil were both fungicidal against C. auris at concentrations less than or equal to 1.25% (v/v). Manuka honey inhibited C. auris at 25% (v/v) concentrations. Among the commercial products tested, manuka body wash and mouthwash were fungicidal against C. auris at concentrations less than or equal to 0.39% (w/v) and 6.25% (v/v) of products as supplied for use, respectively, while tea tree body wash and MedihoneyTM wound gel demonstrated fungistatic properties. In conclusion, this study demonstrated good in vitro antifungal efficacy of tea tree oil, manuka oil, manuka honey, and commercially available antiseptic products containing these active ingredients. Future studies are warranted to evaluate the effectiveness of these antiseptic products in clinical settings.
Candida auris is an emerging superbug fungus that poses a serious threat to global public health. The excellent antifungal efficacy of
natural antiseptics and their commercial hygiene products provide new insights into the development of an alternative decolonization regimen against C. auris.