PDF(Pubmed)
Abstract：
Over millions of years of evolution, nature has developed a myriad of unique features that have inspired the design of adhesives for wound healing. Bionic hydrogel adhesives, capable of adapting to the dynamic movements of tissues, possess superior biocompatibility and effectively promote the healing of both external and internal wounds. This paper provides a systematic review of the design and principles of these adhesives, focusing on the treatment of skin wounds, and explores the feasibility of incorporating nature-inspired properties into their design. The adhesion mechanisms of bionic adhesives are analyzed from both chemical and physical perspectives. Materials from natural and synthetic polymers commonly used as adhesives are detailed regarding their biocompatibility and degradability. The multifunctional design elements of hydrogel adhesives for skin trauma treatment, such as self-healing, drug release, responsive design, and optimization of mechanical and physical properties, are further explored. The aim is to overcome the limitations of conventional treatments and offer a safer, more effective solution for the application of bionic wound dressings.
摘要：
经过数百万年的进化，大自然已经开发了无数的独特功能，激发了伤口愈合粘合剂的设计。仿生水凝胶粘合剂，能够适应组织的动态运动，具有优越的生物相容性，有效促进外部和内部伤口的愈合。本文对这些粘合剂的设计和原理进行了系统的回顾，专注于皮肤伤口的治疗，并探讨了将受自然启发的属性纳入其设计的可行性。从化学和物理两个角度分析了仿生粘合剂的粘合机理。通常用作粘合剂的天然和合成聚合物的材料详细说明了它们的生物相容性和降解性。用于皮肤创伤治疗的水凝胶粘合剂的多功能设计元素，比如自我修复，药物释放，响应式设计，以及机械和物理性能的优化，进一步探索。目的是克服常规治疗的局限性，提供更安全的治疗方法，更有效的解决了仿生伤口敷料的应用。
