天然产物的活性成分,其中包括紫杉醇,姜黄素,藤黄酸,白藜芦醇,雷公藤甲素和雷公藤多酚,有前途的抗炎,抗肿瘤,抗氧化剂,和其他药理活性。然而,由于溶解度低,其临床应用受到限制,不稳定性,低生物利用度,快速新陈代谢,半衰期短,和强烈的脱靶毒性。为了克服这些缺点,基于细胞膜的仿生纳米系统已经出现,可以避免免疫系统的清除,增强目标,延长药物循环,同时还提高了药物的溶解度和生物利用度,增强药物功效,减少副作用。这篇综述总结了细胞膜包被的仿生纳米系统的制备和涂层以及它们在疾病中用于靶向天然产物递送的应用方面的最新进展。当前的挑战,局限性,并讨论了这一领域的前景,为开发用于天然产物的多功能仿生纳米系统提供研究基础。
Active components of natural products, which include paclitaxel, curcumin, gambogic acid, resveratrol, triptolide and celastrol, have promising anti-inflammatory, antitumor, anti-oxidant, and other pharmacological activities. However, their clinical application is limited due to low solubility, instability, low bioavailability, rapid metabolism, short half-life, and strong off-target toxicity. To overcome these drawbacks, cell membrane-based biomimetic
nanosystems have emerged that avoid clearance by the immune system, enhance targeting, and prolong drug circulation, while also improving drug solubility and bioavailability, enhancing drug efficacy, and reducing side effects. This review summarizes recent advances in the preparation and coating of cell membrane-coated biomimetic
nanosystems and in their applications to disease for targeted natural products delivery. Current challenges, limitations, and prospects in this field are also discussed, providing a research basis for the development of multifunctional biomimetic
nanosystems for natural products.