固体纳米分散体(SND)是近年来被广泛研究的一类重要的纳米农药。然而,纳米农药生物活性增强的关键影响因素尚不清楚,这不仅限制了相关机制的探索,但也阻碍了纳米农药的精确设计和开发。在这项研究中,我们探索了SND在增强纳米农药生物活性方面的潜力,特别关注使用自乳化载体固化技术结合参数优化制备的阿维菌素SND。我们的配方,由8%的阿维菌素组成,1%抗氧化剂BHT(2,6-二叔丁基-4-甲基苯酚),12%复合表面活性剂,和79%的苯甲酸钠,显着增加阿维菌素的假溶解度至少3300倍,并将其粒径减小到仅仅15nm,远小于传统的水乳液(EW)和水分散性颗粒(WDG)形式。这种颗粒尺寸的减小和表面活性的增加导致改善的叶面粘附和保留,在不需要有机溶剂的情况下实现更有效的应用。与EW相比,抗氧化剂的加入也增强了光稳定性,整体稳定性测试证实了SND在各种储存条件下的恢复能力。生物活性测试表明,使用阿维菌素SND对小菜蛾(小菜蛾)的毒性显着增加,与EW和WDG相比,其功效高3.7和7.6倍,分别。这些发现强调了小粒径的关键作用,高表面活性,和强大的抗氧化性能,在提高阿维菌素SND的性能和生物活性,突出了它在设计和开发高效率中的重要性,生态友好型纳米农药,为可持续农业实践做出有价值的贡献。
Solid nanodispersion (SND) is an important variety of nanopesticides which have been extensively studied in recent years. However, the key influencing factors for bioactivity enhancement of nanopesticides remain unclear, which not only limits the exploration of relevant mechanisms, but also hinders the precise design and development of nanopesticides. In this study, we explored the potential of SND in enhancing the bioactivity of nanopesticides, specifically focusing on abamectin SND prepared using a self-emulsifying-carrier solidifying technique combined with parameter optimization. Our formulation, consisting of 8% abamectin, 1% antioxidant BHT (2,6-di-tert-butyl-4-methylphenol), 12% complex surfactants, and 79% sodium benzoate, significantly increased the pseudo-solubility of abamectin by at least 3300 times and reduced its particle size to a mere 15 nm, much smaller than traditional emulsion in water (EW) and water-dispersible granule (WDG) forms. This reduction in particle size and increase in surface activity resulted in improved foliar adhesion and retention, enabling a more efficient application without the need for organic solvents. The inclusion of antioxidants also enhanced photostability compared to EW, and overall stability tests confirmed SND\'s resilience under various storage conditions. Bioactivity tests demonstrated a marked increase in toxicity against diamondback moths (Plutella xylostella L.) with abamectin SND, which exhibited 3.7 and 7.6 times greater efficacy compared to EW and WDG, respectively. These findings underscore the critical role of small particle size, high surface activity, and strong antioxidant properties in improving the performance and bioactivity of abamectin SND, highlighting its significance in the design and development of high-efficiency, eco-friendly nanopesticides and contributing valuably to sustainable agricultural practices.