■甲状腺癌的发病率在全球范围内呈上升趋势,儿童暴露于辐射是其出现的唯一公认的催化剂。尽管如此,许多其他可能构成风险的因素正在等待彻底的检查和验证。这项回顾性研究旨在探讨与甲状腺癌相关的恶性肿瘤,并对比患有孤立性肿瘤的人与患有多原发性肿瘤(MPN)的人的生存率。
■这项回顾性研究检查了侯赛因国王癌症中心(KHCC)的数据,乔丹。在563名诊断为甲状腺癌的患者中,30例患者患有甲状腺恶性肿瘤作为MPN的一部分。对于1:3的倾向得分匹配分析,还纳入了90例仅患有原发性甲状腺恶性肿瘤的患者。
■血液和乳腺恶性肿瘤是除甲状腺肿瘤外最常见的癌症。患有MPN的患者在年龄较大时被诊断出,体重指数较高,甲状腺球蛋白抗体水平较高(每次p<0.05)。此外,MPN患者表现出更强的癌症家族史(p=0.002)。135个月的中位随访时间显示,与单发肿瘤患者相比,MPN患者的5年生存率较差(分别为87%和100%;p<0.01)。然而,两组的5年无事件生存率无差异.
■MPN与甲状腺癌患者的生存结果显著改变相关。老年甲状腺癌的诊断,伴有升高的初始甲状腺球蛋白抗体水平和显著的家族性倾向,可能会引起人们对同步或异时性肿瘤的潜在发生的担忧。
UNASSIGNED: The incidence of thyroid cancer is on the rise worldwide, with childhood exposure to radiation being the sole acknowledged catalyst for its emergence. Nonetheless, numerous other factors that may pose risks are awaiting thorough examination and validation. This retrospective study aims to explore the malignancies linked to thyroid cancer and contrast the survival rates of those afflicted with a solitary tumor versus those with multiple primary neoplasms (MPN).
UNASSIGNED: This retrospective study examined data from King Hussein Cancer Center (KHCC), Jordan. Among 563 patients diagnosed with thyroid cancer, 30 patients had thyroid malignancy as part of MPN. For a 1:3 propensity score-matched analysis, 90 patients with only a primary thyroid malignancy were also enrolled.
UNASSIGNED: Hematologic and breast malignancies were among the most frequent observed cancers alongside thyroid neoplasm. Patients who had MPN were diagnosed at older age, had higher body mass index and presented with higher thyroglobulin antibody levels (p < 0.05 for each). Additionally, MPN patient displayed a stronger family history for cancers (p= 0.002). A median follow-up duration of 135 months unveiled that MPN patients faced a worse 5-year survival compared to their counterparts with a singular neoplasm (87% vs 100% respectively; p < 0.01). However, no distinction emerged in the 5-year event-free survival between these two groups.
UNASSIGNED: MPN correlates with a significantly altered survival outcome of thyroid cancer patients. The diagnosis of thyroid carcinoma at an older age, accompanied by elevated initial thyroglobulin antibody levels and a notable familial predisposition, may raise concerns about the potential occurrence of synchronous or metachronous tumors.