UNASSIGNED: Patients undergoing PC surgery from 1975 to 2020 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. Standardized incidence ratios (SIRs) compared observed-to-expected cancers based on U.S. population rates. Cumulative incidence of secondary tumors was analyzed with Cox regression and cancer-specific survival with Kaplan-Meier curves.
UNASSIGNED: Of 6,100 resected PC patients, 267 (4.38%) developed multiple cancers over 6.2 years median follow-up period. Subsequent malignancies showed a rising cumulative incidence extending beyond 5 years. Lung cancer was the predominant second primary in both males (n=36, SIR 1.87) and females (n=32, SIR 2.17). Prostate (n=33) and breast (n=25) cancers were also common. Risk varied by latency period and gender.
UNASSIGNED: Postoperative PC patients face a measurable risk for secondary cancers. Enhanced long-term surveillance has the potential to improve early detection and outcomes in this survivor population. Our data provides real-world evidence which could help inform surveillance guidelines in the future.
■在监测中确定了1975年至2020年接受PC手术的患者,流行病学,和结束结果(SEER)注册表。标准化发病率(SIR)比较了基于美国人口比率的观察到的预期癌症。用Cox回归分析继发性肿瘤的累积发生率,用Kaplan-Meier曲线分析癌症特异性存活。
■在6100例切除的PC患者中,267(4.38%)在6.2年的中位随访期内发展为多种癌症。随后的恶性肿瘤显示超过5年的累积发病率上升。在男性(n=36,SIR1.87)和女性(n=32,SIR2.17)中,肺癌是主要的第二原发性肺癌。前列腺癌(n=33)和乳腺癌(n=25)也很常见。风险因潜伏期和性别而异。
术后PC患者面临可测量的继发性癌症风险。加强长期监测有可能改善这一幸存者群体的早期发现和结果。我们的数据提供了现实世界的证据,可以帮助在未来的监测指南。