PDF(Pubmed)
Abstract：
UNASSIGNED: With improving survival after pancreatic cancer (PC) resection, questions emerge concerning risk and patterns of metachronous tumors. We aimed to determine the incidence of multiple primary cancers among postoperative PC survivors.
UNASSIGNED: Patients undergoing PC surgery from 1975 to 2020 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. Standardized incidence ratios (SIRs) compared observed-to-expected cancers based on U.S. population rates. Cumulative incidence of secondary tumors was analyzed with Cox regression and cancer-specific survival with Kaplan-Meier curves.
UNASSIGNED: Of 6,100 resected PC patients, 267 (4.38%) developed multiple cancers over 6.2 years median follow-up period. Subsequent malignancies showed a rising cumulative incidence extending beyond 5 years. Lung cancer was the predominant second primary in both males (n=36, SIR 1.87) and females (n=32, SIR 2.17). Prostate (n=33) and breast (n=25) cancers were also common. Risk varied by latency period and gender.
UNASSIGNED: Postoperative PC patients face a measurable risk for secondary cancers. Enhanced long-term surveillance has the potential to improve early detection and outcomes in this survivor population. Our data provides real-world evidence which could help inform surveillance guidelines in the future.
UNASSIGNED: Patients undergoing PC surgery from 1975 to 2020 were identified in the Surveillance, Epidemiology, and End Results (SEER) registry. Standardized incidence ratios (SIRs) compared observed-to-expected cancers based on U.S. population rates. Cumulative incidence of secondary tumors was analyzed with Cox regression and cancer-specific survival with Kaplan-Meier curves.
UNASSIGNED: Of 6,100 resected PC patients, 267 (4.38%) developed multiple cancers over 6.2 years median follow-up period. Subsequent malignancies showed a rising cumulative incidence extending beyond 5 years. Lung cancer was the predominant second primary in both males (n=36, SIR 1.87) and females (n=32, SIR 2.17). Prostate (n=33) and breast (n=25) cancers were also common. Risk varied by latency period and gender.
UNASSIGNED: Postoperative PC patients face a measurable risk for secondary cancers. Enhanced long-term surveillance has the potential to improve early detection and outcomes in this survivor population. Our data provides real-world evidence which could help inform surveillance guidelines in the future.
摘要：
■随着胰腺癌（PC）切除术后生存率的提高，关于异时肿瘤的风险和模式的问题出现。我们旨在确定术后PC幸存者中多原发癌的发生率。
■在监测中确定了1975年至2020年接受PC手术的患者，流行病学,和结束结果(SEER)注册表。标准化发病率（SIR）比较了基于美国人口比率的观察到的预期癌症。用Cox回归分析继发性肿瘤的累积发生率,用Kaplan-Meier曲线分析癌症特异性存活。
■在6100例切除的PC患者中，267（4.38％）在6.2年的中位随访期内发展为多种癌症。随后的恶性肿瘤显示超过5年的累积发病率上升。在男性（n=36，SIR1.87）和女性（n=32，SIR2.17）中，肺癌是主要的第二原发性肺癌。前列腺癌（n=33）和乳腺癌（n=25）也很常见。风险因潜伏期和性别而异。
术后PC患者面临可测量的继发性癌症风险。加强长期监测有可能改善这一幸存者群体的早期发现和结果。我们的数据提供了现实世界的证据，可以帮助在未来的监测指南。
■在监测中确定了1975年至2020年接受PC手术的患者，流行病学,和结束结果(SEER)注册表。标准化发病率（SIR）比较了基于美国人口比率的观察到的预期癌症。用Cox回归分析继发性肿瘤的累积发生率,用Kaplan-Meier曲线分析癌症特异性存活。
■在6100例切除的PC患者中，267（4.38％）在6.2年的中位随访期内发展为多种癌症。随后的恶性肿瘤显示超过5年的累积发病率上升。在男性（n=36，SIR1.87）和女性（n=32，SIR2.17）中，肺癌是主要的第二原发性肺癌。前列腺癌（n=33）和乳腺癌（n=25）也很常见。风险因潜伏期和性别而异。
术后PC患者面临可测量的继发性癌症风险。加强长期监测有可能改善这一幸存者群体的早期发现和结果。我们的数据提供了现实世界的证据，可以帮助在未来的监测指南。
