PDF(Pubmed)
Abstract：
Cardiovascular disease (CVD) continues to be the leading cause of death in European men. Atherosclerosis and its clinical consequence, chronic coronary syndrome (CCS), comprise two main elements: dysfunction of lipoprotein metabolism and an important inflammatory component that contributes to the development of complications, including acute coronary syndrome (ACS). Measures of both components are combined in a composite marker called monocyte-to-HDL ratio (MHR). Vitamin D was previously described to influence inflammation processes, and its deficiency influences CVD risk factors. This research describes the differences in MHR and total serum 25-hydroxyvitamin D (25(OH)D) concentration between male patients with different diagnoses of CCS and the correlation between 25(OH)D and MHR in this group. Significant differences were observed between ACS and CCS patients in 25(OH)D and MHR-the highest HDL and serum 25(OH)D concentrations were observed in patients with CCS, whereas the highest value of MHR was observed in patients with STEMI. A significant correlation was observed between 25(OH)D, HDL, and MHR. Due to the significant but small nominal difference in MHR values between groups of patients diagnosed with ACS and CCS, and the possible influence of age and hyperlipidemia status on the differences in vitamin D levels in these groups, this subject requires further well-designed research. The suggested bidirectional relationship between MHR and 25(OH)D and the role of MHR as a predictor of vitamin D status in the body also needs to be verified.
摘要：
心血管疾病（CVD）仍然是欧洲男性死亡的主要原因。动脉粥样硬化及其临床后果，慢性冠状动脉综合征（CCS），包括两个主要因素：脂蛋白代谢功能障碍和有助于并发症发展的重要炎症成分，包括急性冠脉综合征（ACS）。两种组分的测量值组合在称为单核细胞与HDL比率(MHR)的复合标记物中。维生素D以前被描述为影响炎症过程，其缺乏影响心血管疾病的危险因素。这项研究描述了不同CCS诊断的男性患者之间MHR和总血清25-羟基维生素D（25（OH）D）浓度的差异以及该组中25（OH）D与MHR之间的相关性。ACS和CCS患者在25（OH）D和MHR之间观察到显着差异-在CCS患者中观察到最高的HDL和血清25（OH）D浓度。而在STEMI患者中MHR值最高。25(OH)D,HDL,和MHR。由于诊断为ACS和CCS的患者组之间的MHR值存在显著但较小的名义差异,以及年龄和高脂血症状态对这些人群维生素D水平差异的可能影响，这个问题需要进一步精心设计的研究。MHR和25（OH）D之间的双向关系以及MHR作为体内维生素D状态预测因子的作用也需要验证。
