背景:作为靶向囊泡单胺转运蛋白2(VMAT2)的生物标志物,18F-9-氟丙基二氢丁苯那嗪(18F-FP-DTBZ)正电子发射断层扫描(PET)在诊断帕金森病(PD)和评估其严重程度方面非常准确。然而,进行性核上性麻痹(PSP)患者证据不足.
目的:我们评估了PSP的纹状体和纹状体外单胺能破坏以及PSP患者之间模式的差异,PD,和健康对照(HCs)使用18F-FP-DTBZPET,以及与PSP临床特征的相关性。
方法:我们招募了58例PSP患者,23名年龄和病程匹配的PD患者,以及17个HC。患者使用18F-FP-DTBZPET/计算机断层扫描进行扫描,和图像根据感兴趣的体积进行空间归一化和分析。
结果:VMAT2结合在纹状体和黑质中各组间差异显著(P<0.001)。与PD组相比,PSP组的尾状破坏更严重(P<0.001)。然而,伏隔核没有发现差异,海马体,杏仁核,或PD和PSP组之间的关系。在PSP组中,纹状体VMAT2结合与PSP评定量表的跌倒/姿势稳定性亚分显著相关,尤其是在壳核中。此外,VMAT2结合与海马的简易精神状态检查或蒙特利尔认知评估相关。
结论:尾状破坏在各组间显示出显著差异。纹状体和海马中的VAMT2结合反映了跌倒/姿势稳定性和认知的严重程度,分别。©2024国际帕金森和运动障碍协会。
BACKGROUND: As a biomarker targeting vesicular
monoamine transporter 2 (VMAT2), 18F-9-fluoropropyldihydrotetrabenazine (18F-FP-DTBZ) positron emission tomography (PET) is highly accurate in diagnosing Parkinson\'s disease (PD) and assessing its severity. However, evidence is insufficient in patients with progressive supranuclear palsy (PSP).
OBJECTIVE: We evaluated the striatal and extrastriatal monoaminergic disruption of PSP and differences in patterns between patients with PSP, PD, and healthy controls (HCs) using 18F-FP-DTBZ PET, as well as its correlations with the clinical characteristics of PSP.
METHODS: We recruited 58 patients with PSP, 23 age- and duration-matched patients with PD, as well as 17 HCs. Patients were scanned using 18F-FP-DTBZ PET/computed tomography, and images were spatially normalized and analyzed based on the volume of interest.
RESULTS: VMAT2 binding differed significantly in the striatum and substantia nigra among the groups (P < 0.001). A more severe disruption in the caudate was noted in the PSP group (P < 0.001) than in the PD group. However, no differences were found in the nucleus accumbens, hippocampus, amygdala, or raphe between the PD and PSP groups. Within the PSP group, striatal VMAT2 binding was significantly associated with the fall/postural stability subscore of the PSP Rating Scale, especially in the putamen. Furthermore, VMAT2 binding was correlated with Mini-Mental State Examination or Montreal Cognitive Assessment in the hippocampus.
CONCLUSIONS: Caudate disruptions showed prominent differences among the groups. VAMT2 binding in the striatum and hippocampus reflects the severity of fall/postural stability and cognition, respectively. © 2024 International Parkinson and Movement Disorder Society.