颅内压是交感神经活动的决定因素之一,睡眠磨牙症与交感神经活动增加有关。本研究旨在研究低Fowler睡眠位置和醋甲唑胺治疗对睡眠磨牙症患者节律性咀嚼肌活动/睡眠磨牙症发作的影响。在低Fowler位(15°-30°)或仰卧位(n=11)的睡眠磨牙症患者进行多导睡眠图记录,并使用醋甲唑胺或安慰剂治疗(100毫克,睡前3-4小时,P.O.,n=9),并确定了在低Fowler位置或使用醋甲唑胺治疗的睡眠过程中睡眠变量和心率变化。睡眠磨牙症指数,每小时睡眠的咬肌肌电图爆发次数,节律性咀嚼肌活动/睡眠磨牙症持续时间与总睡眠持续时间之比,肢体总运动指数,具有节律性咀嚼肌活动的肢体运动指数,与仰卧位和安慰剂摄入后相比,在低Fowler位置和摄入醋甲唑胺后每小时睡眠中的睡眠磨牙症簇数量显着减少(p<0.05-0.001),分别。在低Fowler位置的非快速眼动睡眠阶段2(N2)和使用醋甲唑胺治疗期间的低频心率方差功率显着低于仰卧位和安慰剂治疗期间的睡眠期间的低频心率方差功率(p<0.05)。分别。总之,在低Fowler位置的睡眠和醋甲唑胺治疗与节律性咀嚼肌活动/睡眠磨牙症发作的发生显著减少相关,这可能是由于主要在非快速眼动睡眠阶段2期间颅内压和交感神经活动降低。
Intracranial pressure is one of the determinants of sympathetic activities, and sleep bruxism is associated with increased sympathetic activities. This study aimed to investigate effects of the low Fowler\'s sleep position and
methazolamide treatment on the occurrence of rhythmic masticatory muscle activities/sleep bruxism episodes in patients with sleep bruxism in a randomized controlled trial. Polysomnographic recordings were performed on the patients with sleep bruxism sleeping in the low Fowler\'s (15°-30°) or supine position (n = 11), and with
methazolamide or placebo treatment (100 mg, 3-4 hr before bedtime, P.O., n = 9), and changes in sleep variables and heart rate variance during sleep in the low Fowler\'s position or with
methazolamide treatment were determined. Sleep bruxism index, number of masseter muscle electromyographic bursts per hour of sleep, ratio of rhythmic masticatory muscle activities/sleep bruxism duration to the total sleep duration, index of total limb movements, index of limb movements with rhythmic masticatory muscle activities, and number of sleep bruxism clusters per hour of sleep in the low Fowler\'s position and after methazolamide intake were significantly smaller (p < 0.05-0.001) than those in the supine position and after placebo intake, respectively. The low-frequency heart rate variance powers during non-rapid eye movement sleep stage 2 (N2) in the low Fowler\'s position and with
methazolamide treatment were significantly lower (p < 0.05) than those during sleep in the supine position and with placebo treatment, respectively. In conclusion, sleep in the low Fowler\'s position and
methazolamide treatment were associated with significant decreases in the occurrence of rhythmic masticatory muscle activities/sleep bruxism episodes, which might be due to a reduction in intracranial pressure and sympathetic activities mainly during non-rapid eye movement sleep stage 2.