Abstract：
UNASSIGNED: Carbonic anhydrases (CAs, EC 4.2.1.1) have been established drug targets for decades, with their inhibitors and activators possessing relevant pharmacological activity and applications in various fields. At least 11 sulfonamides/sulfamates are clinically used as diuretics, antiglaucoma, antiepileptic, or antiobesity agents and one derivative, SLC-0111, is in clinical trials as antitumor/antimetastatic agent. The activators were less investigated with no clinically used agent.
UNASSIGNED: Drug interactions between CA inhibitors/activators and various other agents are reviewed in publications from the period March 2020 - January 2024.
UNASSIGNED: Drug interactions involving these agents revealed several interesting findings. Acetazolamide plus loop diuretics is highy effective in acute decompensated heart failure, whereas ocular diseases such as X-linked retinoschisis and macular edema were treated by acetazolamide plus bevacizumab or topical NSAIDs. Potent anti-infective effects of acetazolamide and other CAIs, alone or in combination with other agents were demonstrated for the management of Neisseria gonorrhoea, vancomycin resistant enterococci, Acanthamoeba castellanii, Trichinella spiralis, and Cryptococcus neoformans infections. Topiramate, in combination with phentermine is incresingly used for the management of obesity, whereas zonisamide plus levodopa is highly effective for Parkinson\'s disease. Acetazolamide, methazolamide, ethoxzolamide, and SLC-0111 showed synergistic antitumor/antimetastatic action in combination with many other antitumor drugs.
UNASSIGNED: Drug interactions between CA inhibitors/activators and various other agents are reviewed in publications from the period March 2020 - January 2024.
UNASSIGNED: Drug interactions involving these agents revealed several interesting findings. Acetazolamide plus loop diuretics is highy effective in acute decompensated heart failure, whereas ocular diseases such as X-linked retinoschisis and macular edema were treated by acetazolamide plus bevacizumab or topical NSAIDs. Potent anti-infective effects of acetazolamide and other CAIs, alone or in combination with other agents were demonstrated for the management of Neisseria gonorrhoea, vancomycin resistant enterococci, Acanthamoeba castellanii, Trichinella spiralis, and Cryptococcus neoformans infections. Topiramate, in combination with phentermine is incresingly used for the management of obesity, whereas zonisamide plus levodopa is highly effective for Parkinson\'s disease. Acetazolamide, methazolamide, ethoxzolamide, and SLC-0111 showed synergistic antitumor/antimetastatic action in combination with many other antitumor drugs.
摘要：
■。碳酸酐酶（CA，EC4.2.1.1)已经建立了几十年的药物靶标，它们的抑制剂和活化剂具有相关的药理活性和在各个领域的应用。临床上至少有11种磺胺类/氨基磺酸盐用作利尿剂，抗青光眼,抗癫痫药,或抗肥胖药和一种衍生物，SLC-0111正在临床试验中作为抗肿瘤/抗转移剂。在没有临床使用的药剂的情况下,对活化剂的研究较少。
■CA抑制剂/激活剂与各种其他药物之间的药物相互作用在2020年3月至2024年1月的出版物中进行了综述。
■涉及这些药物的药物相互作用揭示了几个有趣的发现。乙酰唑胺加环利尿剂对急性失代偿性心力衰竭有很高的疗效，而眼部疾病如X连锁视网膜裂孔和黄斑水肿则通过乙酰唑胺联合贝伐单抗或外用NSAIDs治疗.乙酰唑胺和其他CAIs的强效抗感染作用，单独或与其他药物联合用于治疗淋病奈瑟菌，耐万古霉素肠球菌,棘阿米巴,旋毛虫和新生隐球菌感染。托吡酯,与芬特明联合用于肥胖的管理，而唑尼沙胺加左旋多巴治疗帕金森病非常有效。乙酰唑胺,醋甲唑胺,乙恶唑胺和SLC-0111与许多其他抗肿瘤药物联合显示出协同抗肿瘤/抗转移作用。
■CA抑制剂/激活剂与各种其他药物之间的药物相互作用在2020年3月至2024年1月的出版物中进行了综述。
■涉及这些药物的药物相互作用揭示了几个有趣的发现。乙酰唑胺加环利尿剂对急性失代偿性心力衰竭有很高的疗效，而眼部疾病如X连锁视网膜裂孔和黄斑水肿则通过乙酰唑胺联合贝伐单抗或外用NSAIDs治疗.乙酰唑胺和其他CAIs的强效抗感染作用，单独或与其他药物联合用于治疗淋病奈瑟菌，耐万古霉素肠球菌,棘阿米巴,旋毛虫和新生隐球菌感染。托吡酯,与芬特明联合用于肥胖的管理，而唑尼沙胺加左旋多巴治疗帕金森病非常有效。乙酰唑胺,醋甲唑胺,乙恶唑胺和SLC-0111与许多其他抗肿瘤药物联合显示出协同抗肿瘤/抗转移作用。
