PDF(Pubmed)
Abstract：
Methazolamide is used to treat patients with glaucoma. However, as a sulfonamide derivative, methazolamide shares the same adverse reaction profile as other sulfa-based medications. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare delayed-type hypersensitivity cutaneous reactions with high morbidity and mortality. Here, we report a severe SJS/TEN overlap syndrome in an 85-year-old Chinese male patient who received methazolamide 25 mg twice daily for his left eye glaucoma. The causal relationship between SJS/TEN and methazolamide was categorized as \"highly likely\" on the algorithm for assessing drug causality for epidermal necrolysis. In addition to the treatments with methylprednisolone and immunoglobulin, we used a special electromagnetic spectrum therapeutic apparatus to provide skin wound care. The patient had a thoroughly satisfying recovery. This is the first case report to use electromagnetic field therapy in a patient with SJS/TEN. We share our experience here and suggest that electromagnetic field therapy can provide advanced skin wound care and facilitate the recovery of SJS/TEN.
摘要：
甲唑胺用于治疗青光眼患者。然而,作为磺酰胺衍生物，与其他磺胺类药物具有相同的不良反应。Stevens-Johnson综合征（SJS）和中毒性表皮坏死松解症（TEN）是罕见的迟发型超敏反应性皮肤反应，具有较高的发病率和死亡率。这里,我们报告了1例85岁的中国男性患者的严重SJS/TEN重叠综合征,该患者接受了25mg/2次/2次/2次/2次/2次/2次的醋甲唑胺治疗.在评估表皮坏死松解的药物因果关系的算法中，SJS/TEN和醋甲唑胺之间的因果关系被归类为“极有可能”。除了甲基强的松龙和免疫球蛋白的治疗，我们使用特殊的电磁频谱治疗仪提供皮肤伤口护理。病人完全满意地康复了。这是第一例SJS/TEN患者使用电磁场治疗的病例报告。我们在这里分享我们的经验，并建议电磁场疗法可以提供先进的皮肤伤口护理，并促进SJS/TEN的恢复。
