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Fifty years of research has transformed our understanding of bacterial movement from one of description, based on a limited number of electron micrographs and some low-magnification studies of cells moving towards or away from chemical effectors, to probably the best understood behavioural system in biology. We have a molecular understanding of how bacteria sense and respond to changes in their environment and detailed structural insights into the workings of one of the most complex motor structures we know of. Thanks to advances in genomics we also understand how, through evolution, different species have tuned and adapted a core shared system to optimize behaviour in their specific environment. In this review, I will highlight some of the unexpected findings we made during my over 40-year career, how those findings changed some of our understanding of bacterial behaviour and biochemistry and some of the battles to have those observations accepted.

Genetics has become a critical component of medicine over the past five to six decades. Alongside genetics, a relatively new discipline, dysmorphology, has also begun to play an important role in providing critically important diagnoses to individuals and families. Both have become indispensable to unraveling rare diseases. Almost every medical specialty relies on individuals experienced in these specialties to provide diagnoses for patients who present themselves to other doctors. Additionally, both specialties have become reliant on molecular geneticists to identify genes associated with human disorders. Many of the medical geneticists, dysmorphologists, and molecular geneticists traveled a circuitous route before arriving at the position they occupied. The purpose of collecting the memoirs contained in this article was to convey to the reader that many of the individuals who contributed to the advancement of genetics and dysmorphology since the late 1960s/early 1970s traveled along a journey based on many chances taken, replying to the necessities they faced along the way before finding full enjoyment in the practice of medical and human genetics or dysmorphology. Additionally, and of equal importance, all exhibited an ability to evolve with their field of expertise as human genetics became human genomics with the development of novel technologies.

OBJECTIVE: The complexities surrounding aging, dementia, and care are timely issues that transcend beyond institutional boundaries, evincing a critical debate on later life across disciplines. The aim of this study is to offer fresh insights into the intricate paradigms of living and growing older with dementia. The study focuses on the Nobel Prize-winning author Annie Ernaux\'s memoir I Remain in Darkness (1999), which provides a candid account of her mother\'s journey through dementia from its onset to the gradual decline.
METHODS: This article employs the theoretical frameworks of literary gerontology, illness narratives and life writing to address the challenges of aging, dementia and care that are represented in Ernaux\'s memoir. It also addresses societal attitudes and stigma associated with aging and dementia by exploring the embarrassment that individuals and families experience when confronted with the deteriorating mental health of their loved ones.
RESULTS: Ernaux\'s memoir explores the nuances of dementia and caregiving within both the familial and institutional context, and sheds light on the complex relationship between a mother and a daughter. Through the act of witnessing, Ernaux embarks on a path of healing, which allows her to confront her past wounds and better navigate the challenges that lie ahead. However, Ernaux\'s confessional memoir also troubles the ethics of life writing and identity issues, and seems to perpetuate the pathologizing medical gaze through the exposure of her mother\'s vulnerability and intimacy in the face of dementia and care.
CONCLUSIONS: Ernaux\'s account of her mother\'s dementia and aging is both a confessional piece of writing and a narrative therapy, which reveals the challenges of aging, illness, and unresolved family tensions. Her work illuminates the interconnectedness between the past, present, and future, and shows that illness narratives can act as a catalyst for transformative change, identity formation, and self-reflection. The article addresses the intricacies of old age, showcasing how life writing and humanities-based inquiry can bring to the fore key aspects of the latest stages in life, which are often unvoiced because they represent the most unpleasant and feared aspects of aging in contemporary society.

This article was migrated. The article was marked as recommended. Life-writing is an increasingly recognized genre including, among other forms of expression, biography, memoir, journals, diaries and letters. In addition to providing a source of information about potentially significant historical and social dimensions of medicine, the life-writing of physicians also offers the public a greater sense of the writers\' inner lives and provides a resource of wisdom and companionship to other physicians and health care professionals across time and various stages of personal and professional development. This kind of life-writing, when considered alongside patient accounts, can further contribute to what Anne Hunsaker Hawkins has called \"a medicine that is truly human\".

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It is not yet clear how nostalgia achieves the wide-ranging benefits on wellbeing documented by research. Much of the research favorable to nostalgia has employed experimental and quantitative methods within a laboratory setting. Literature and memoir offer a wider range of content for exploration into the complexity of nostalgia. Literature, memoir, and laboratory research have all illustrated the role of nostalgia in sustaining meaning, identity, and social connectedness. However, initial insights from this appraisal suggest a stronger emphasis in literary forms on the role of nostalgia in resolving conflict and coping with change and loss. Literary forms supplement laboratory efforts by providing a greater diversity of life experience and reflections that can yield more integrative syntheses over time.

This essay analyzes how traditional notions of family are \"queered\" in contemporary memoir. I explore how heterosexual coupling becomes unnatural, undermining its equation with reproduction-and even the predictable forward march of family time becomes circular, haunted by alternate kinship models. I refer to this dynamic as \"akin to kin\" to consider how these representations both approximate and depart from normative ideas of family. I analyze several contemporary family memoirs to tease out moments in which \"family\" is imagined otherwise through queer relationalities.

Almost since its inception, punk has been declared dead. What does it mean to live attached to something that is always, at least a little bit, gone? Examining how Justin Pearson merges personal accounts of death and mourning with a sense of punk that is rooted in loss in his memoir of his participation in a North American punk culture since the 1990s, From the Graveyard of the Arousal Industry, this article considers how a focus on living in the wake of the death of punk might shift scholarly and popular narratives told about punk. Punk outlives its death in the 1970s with a redemptive rebirth in which it became the subject of an anti-capitalist narrative. The article considers how Pearson\'s memoir explores a different framework by insisting that punk may not be able to separate itself from the wider world, and that while this might appear to deal a death blow to punk, it also names a persistent set of conditions that define punk. After placing the memoir in the context of this redemptive account of punk as well as among those who see its limits, the article offers an analysis of several scenes addressing personal losses that merge with Pearson\'s attachment to punk-as-something-dead-and-gone. The deaths that Pearson associates with punk rock are personal, but they also register the larger significance of loss for a subculture that cannot stop declaring its own demise, including especially the loss of a fantasy that sees punk as a refuge from the world.

This essay summarizes some of my findings while studying primates in the field from 1962 to 2018. Although I have studied primates throughout the tropics, I focused on Africa, primarily the Kibale Forest of Uganda. My research began in the early days of primate field studies when very little was known about the behavior and ecology of most species. Consequently, I was able to study nearly anything that could be observed under natural conditions. It was not necessary to specialize, and I opted to be a generalist. In much of my work I have attempted to understand the relationships between habitat quality, social organization, and population dynamics, emphasizing the great intraspecific variability that exists over time and between areas. Vocalizations have also long been of interest to me, starting with a description of predator-specific alarm calls and later showing how vocalizations among African monkeys appear to be evolutionarily stable. As my field experience progressed, I became increasingly involved with the conservation of tropical rain forests. In the last part of this essay I offer my thoughts on current trends in field primatology and some advice to the next generation of field biologists, stressing the importance of being a naturalist.