PDF(Pubmed)
Abstract：
Fifty years of research has transformed our understanding of bacterial movement from one of description, based on a limited number of electron micrographs and some low-magnification studies of cells moving towards or away from chemical effectors, to probably the best understood behavioural system in biology. We have a molecular understanding of how bacteria sense and respond to changes in their environment and detailed structural insights into the workings of one of the most complex motor structures we know of. Thanks to advances in genomics we also understand how, through evolution, different species have tuned and adapted a core shared system to optimize behaviour in their specific environment. In this review, I will highlight some of the unexpected findings we made during my over 40-year career, how those findings changed some of our understanding of bacterial behaviour and biochemistry and some of the battles to have those observations accepted.
摘要：
五十年的研究改变了我们对细菌运动的理解，基于有限数量的电子显微照片和一些低放大倍数的细胞朝向或远离化学效应物的研究，可能是生物学中最容易理解的行为系统。我们对细菌如何感知和响应其环境变化有分子理解，并对我们所知的最复杂的运动结构之一的工作原理有详细的结构见解。由于基因组学的进步，我们也明白了，通过进化，不同的物种已经调整和调整了一个核心共享系统，以优化其特定环境中的行为。在这次审查中,我将强调我们在40多年的职业生涯中取得的一些意想不到的发现，这些发现如何改变了我们对细菌行为和生物化学的理解，以及为接受这些观察而进行的一些斗争。
