Abstract：
OBJECTIVE: As obesity and chronic kidney disease (CKD) remain a public health issue, we aim to elaborate on their complex relationship regarding pathogenetic mechanisms and therapeutic potential as well. The purpose of this review is to enhance our understanding of the interplay between obesity and CKD in order to timely diagnose and treat obesity-related CKD.
RESULTS: Obesity and CKD pose significant intertwined challenges to global health, affecting a substantial portion of the population worldwide. Obesity is recognized as an independent risk factor, intricately contributing to CKD pathogenesis through mechanisms such as lipotoxicity, chronic inflammation, and insulin resistance. Recent evidence highlights additional factors including hemodynamic changes and intestinal dysbiosis that exacerbate kidney dysfunction in obese individuals, leading to histologic alterations known as obesity-related glomerulopathy (ORG). This narrative review synthesizes current knowledge on the prevalence, pathophysiology, clinical manifestations, and diagnostic strategies of obesity-related kidney disease. Furthermore, it explores mechanistic insights to delineate current therapeutic approaches, future directions for managing this condition and controversies. By elucidating the multifaceted interactions between obesity and kidney health, this review aims to inform clinical practice and stimulate further research to address this global health epidemic effectively.
RESULTS: Obesity and CKD pose significant intertwined challenges to global health, affecting a substantial portion of the population worldwide. Obesity is recognized as an independent risk factor, intricately contributing to CKD pathogenesis through mechanisms such as lipotoxicity, chronic inflammation, and insulin resistance. Recent evidence highlights additional factors including hemodynamic changes and intestinal dysbiosis that exacerbate kidney dysfunction in obese individuals, leading to histologic alterations known as obesity-related glomerulopathy (ORG). This narrative review synthesizes current knowledge on the prevalence, pathophysiology, clinical manifestations, and diagnostic strategies of obesity-related kidney disease. Furthermore, it explores mechanistic insights to delineate current therapeutic approaches, future directions for managing this condition and controversies. By elucidating the multifaceted interactions between obesity and kidney health, this review aims to inform clinical practice and stimulate further research to address this global health epidemic effectively.
摘要：
目标：由于肥胖和慢性肾病（CKD）仍然是一个公共卫生问题，我们的目的是详细阐述它们在发病机制和治疗潜力方面的复杂关系。这篇综述的目的是加强我们对肥胖和CKD之间相互作用的理解，以便及时诊断和治疗肥胖相关的CKD。
结果：肥胖和CKD对全球健康构成了相互交织的重大挑战，影响了全世界很大一部分人口。肥胖是公认的独立危险因素,通过脂毒性等机制复杂地促进CKD发病机理，慢性炎症，和胰岛素抵抗。最近的证据强调了其他因素，包括血液动力学变化和肠道菌群失调，这些因素加剧了肥胖个体的肾功能不全。导致组织学改变，称为肥胖相关性肾小球病（ORG）。这篇叙述性综述综合了目前关于患病率的知识，病理生理学,临床表现，肥胖相关肾脏疾病的诊断策略。此外，它探索了机械的见解来描绘当前的治疗方法，管理这种情况和争议的未来方向。通过阐明肥胖与肾脏健康之间的多方面相互作用，这篇综述旨在为临床实践提供信息，并促进进一步的研究，以有效应对这一全球健康流行病。
结果：肥胖和CKD对全球健康构成了相互交织的重大挑战，影响了全世界很大一部分人口。肥胖是公认的独立危险因素,通过脂毒性等机制复杂地促进CKD发病机理，慢性炎症，和胰岛素抵抗。最近的证据强调了其他因素，包括血液动力学变化和肠道菌群失调，这些因素加剧了肥胖个体的肾功能不全。导致组织学改变，称为肥胖相关性肾小球病（ORG）。这篇叙述性综述综合了目前关于患病率的知识，病理生理学,临床表现，肥胖相关肾脏疾病的诊断策略。此外，它探索了机械的见解来描绘当前的治疗方法，管理这种情况和争议的未来方向。通过阐明肥胖与肾脏健康之间的多方面相互作用，这篇综述旨在为临床实践提供信息，并促进进一步的研究，以有效应对这一全球健康流行病。
