Abstract：
Type 2 diabetes mellitus (T2DM) is a widespread chronic disease characterized by persistent hyperglycemia, leading to severe complications such as diabetic cardiomyopathy and nephropathy, significantly affecting patient health and quality of life. The complex mechanisms underlying these complications include chronic inflammation, oxidative stress, and metabolic dysregulation. Diabetic cardiomyopathy, marked by structural and functional heart abnormalities, and diabetic nephropathy, characterized by progressive kidney damage, are major contributors to the increased morbidity and mortality associated with T2DM. AdipoRon, a synthetic adiponectin receptor agonist, has shown potential in preclinical studies for mimicking the beneficial effects of endogenous adiponectin, reducing inflammation and oxidative stress, and improving lipid metabolism and mitochondrial function. This systematic review evaluates the therapeutic potential of AdipoRon, focusing on its impact on diabetic cardiomyopathy and nephropathy. Through a comprehensive literature search and analysis, we highlight AdipoRon\'s role in ameliorating cardiovascular and renal complications in various animal models and cellular systems. The findings underscore the urgent need for translational clinical studies to validate AdipoRon\'s efficacy and safety in human populations, aiming to advance this promising therapeutic approach from experimental models to clinical application, potentially offering new hope for improved management of diabetic complications.
摘要：
2型糖尿病（T2DM）是一种以持续高血糖为特征的广泛存在的慢性疾病，导致严重的并发症，如糖尿病性心肌病和肾病，显著影响患者健康和生活质量。这些并发症的复杂机制包括慢性炎症，氧化应激，和代谢失调。糖尿病心肌病,以心脏结构和功能异常为特征，糖尿病肾病，以进行性肾损伤为特征，是T2DM发病率和死亡率增加的主要原因。AdipoRon,合成的脂联素受体激动剂，在临床前研究中显示了模仿内源性脂联素有益作用的潜力，减少炎症和氧化应激，改善脂质代谢和线粒体功能。这篇系统综述评估了AdipoRon的治疗潜力，关注其对糖尿病心肌病和肾病的影响。通过全面的文献检索和分析,我们强调了AdipoRon在各种动物模型和细胞系统中改善心血管和肾脏并发症的作用。这些发现强调了转化临床研究的迫切需要，以验证AdipoRon在人群中的疗效和安全性。旨在将这种有前途的治疗方法从实验模型推进到临床应用，可能为改善糖尿病并发症的管理提供新的希望。
