背景:鉴于家族性地中海热(FMF)的强烈遗传背景,FMF患儿中经常报告的共存疾病也应在其他家庭成员中进行调查。因此,在本研究中,我们旨在检查FMF儿科患者的一级亲属(FDRs)的医疗状况.
方法:儿童449FMF的FDRs慢性疾病,147名青少年特发性关节炎(JIA)患者和93名健康对照(HC)在连续9个月的常规临床就诊中接受了询问。
结果:共1975个FDR,共449个FMF,147名JIA患者的690名FDRs,研究中纳入了406例93HC的FDRs。最常见的医疗条件是非特应性哮喘(n=71,3.6%),2型DM(n=14,2%),FMF的扁桃体切除术史(n=12,2.95%),JIA,和HC组,分别。特应性疾病(FMF与JIA:p=0.013;FMF与HC:p=0.014),风湿性疾病(FMF与JIA:p=0.030;FMF与HC:p=0.017),和手术史(FMF与JIA:p<0.01;FMF与HC:p=0.026),包括腺样体切除术,扁桃体切除术,和阑尾切除术,在FMF组中明显高于其他组。
结论:我们的新发现可能有助于了解FMF患儿共存疾病的遗传负担,并鼓励涉及遗传筛查的进一步研究。
BACKGROUND: Given the strong genetic background of familial Mediterranean fever (FMF), the frequently reported co-existing diseases in children with FMF should also be investigated in other family members. Therefore, we aimed to examine the medical conditions of first-degree relatives (FDRs) of our pediatric patients with FMF in the present study.
METHODS: Chronic diseases of FDRs of pediatric 449 FMF, 147
juvenile idiopathic arthritis (JIA) patients and 93 healthy controls (HC) were questioned during their routine clinical visits for 9 consecutive months.
RESULTS: A total of 1975 FDRs of 449 FMF, 690 FDRs of 147 JIA patients, and 406 FDRs of 93 HC were included into the study. The most common medical conditions were non-atopic asthma (n=71, 3.6%), type 2 DM (n=14, 2%), and tonsillectomy history (n=12, 2.95%) in the FMF, JIA, and HC groups, respectively. Atopic diseases (FMF vs. JIA: p=0.013; FMF vs. HC: p=0.014), rheumatic diseases (FMF vs. JIA: p=0.030; FMF vs. HC: p=0.017), and surgical histories (FMF vs. JIA: p<0.01; FMF vs. HC: p=0.026), including adenoidectomy, tonsillectomy, and appendectomy, were significantly more common in the FMF group than in other groups.
CONCLUSIONS: Our novel findings may contribute to understanding the hereditary burden of co-existing diseases in children with FMF and encourage further studies involving genetic screenings.