■炎症参与近视的发展。n-3多不饱和脂肪酸(n-3PUFA)具有血管舒张和抗炎作用,这可能与控制近视有关。探讨n-3PUFA摄入量与青少年近视的关系,对通过饮食干预控制和缓解青少年近视具有重要意义。
■社会人口统计数据,营养素摄入量的信息,可替宁,PUFA,在这项横断面研究中,从国家健康和营养检查调查(NHANES)数据库中提取了1,128名青少年的眼睛屈光状态。PUFA含有总多不饱和脂肪酸(TPFAs),α-亚麻酸,十八碳四烯酸,二十碳五烯酸(EPA),二十二碳五烯酸(DPA),和二十二碳六烯酸(DHA)。通过比较正常视力组之间的协变量进行筛选,低度近视,和高度近视。n-3PUFA摄入量与青少年近视风险之间的关联使用单变量和多变量逻辑回归分析(优势比)和95%置信区间(CI)进行评估。
■在青少年中,788(70.68%)视力正常,299(25.80%)患有低近视,高度近视41例(3.52%)。三组之间EPA和DHA的平均摄入量存在显着差异,正常视力组的DPA和DHA摄入量均低于低近视组(P<0.05)。调整后的年龄,性别,TPFAs,和可替宁,青少年饮食中EPA的高摄入量(≥11mg/1,000kcal)似乎与高度近视的风险有关(OR=0.39,95%CI:0.18-0.85),而n-3PUFA摄入量与低近视风险之间未发现显著关联.
■饮食中EPA的高摄入量可能与青少年高度近视的风险降低有关。需要进一步的前瞻性研究来验证这一观察结果。
UNASSIGNED: Inflammation is involved in the development of myopia. n-3 polyunsaturated fatty acids (n-3 PUFAs) have vasodilating and anti-inflammatory effects, which may be involved in controlling myopia. It is of great significance to explore the relationship between n-3 PUFA intakes and
juvenile myopia in order to control and alleviate myopia among teenagers through dietary intervention.
UNASSIGNED: Sociodemographic data, information of nutrient intakes, cotinine, PUFAs, and eye refractive status of 1,128 juveniles were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. PUFAs contained total polyunsaturated fatty acid (TPFAs), alpha-linolenic acid, octadecatetraenoic acid, eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Covariates were screened by comparison among groups of normal vision, low myopia, and high myopia. The association between n-3 PUFA intakes and the risk of
juvenile myopia was evaluated using univariate and multivariate logistic regression analyses with odds ratios (ORs) and 95% confidence intervals (CIs).
UNASSIGNED: Among the juveniles, 788 (70.68%) had normal vision, 299 (25.80%) had low myopia, and 41 (3.52%) had high myopia. There were significant differences in average EPA and DHA intakes among the three groups, and mean DPA and DHA intakes in the normal vision group were lower than those in the low myopia group (P < 0.05). After adjustment for age, gender, TPFAs, and cotinine, a high dietary intake of EPA (≥11 mg/1,000 kcal) in juveniles seemed to be associated with the risk of high myopia (OR = 0.39, 95% CI: 0.18-0.85), while no significant associations were identified between n-3 PUFA intakes and the risk of low myopia.
UNASSIGNED: A high dietary intake of EPA may be associated with a decreased risk of high myopia among juveniles. A further prospective study is needed to validate this observation.