先前的研究已经将血清代谢物水平与虹膜睫状体炎联系起来,然而,他们的因果关系仍有待探索。本研究通过使用孟德尔随机化(MR)和连锁不平衡评分回归(LDSC)分析全基因组关联研究(GWAS)中7824例虹膜睫状体炎患者的汇总数据,调查了这种潜在的因果关系。采用严格的质量控制和全面的统计方法,包括敏感性分析,我们检测了486种血清代谢物对虹膜睫状体炎的影响。我们的MR分析确定了23种对虹膜睫状体炎具有显著因果影响的代谢物,包含17种已知代谢物和6种未知代谢物。使用Cochran'sQ检验和MR-PRESSO进一步细化,提示16种代谢物与虹膜睫状体炎风险显著相关。LDSC强调了某些代谢物的遗传力,强调遗传对他们水平的影响。值得注意的是,色氨酸,脯氨酸,可可碱,7-甲基黄嘌呤是危险因素,而3,4-二羟基丁酸酯则表现出保护性。这些发现增强了我们对虹膜睫状体炎代谢相互作用的理解,提供诊断见解,解开病理生理机制,并告知预防和个性化治疗的潜在途径。
Previous research has linked serum metabolite levels to
iridocyclitis, yet their causal relationship remains unexplored. This study investigated this potential causality by analyzing pooled data from 7824
iridocyclitis patients in a Genome-Wide Association Study (GWAS) using Mendelian randomization (MR) and linkage disequilibrium score regression (LDSC). Employing rigorous quality control and comprehensive statistical methods, including sensitivity analyses, we examined the influence of 486 serum metabolites on iridocyclitis. Our MR analysis identified 23 metabolites with significant causal effects on
iridocyclitis, comprising 17 known and 6 unidentified metabolites. Further refinement using Cochran\'s Q test and MR-PRESSO indicated 16 metabolites significantly associated with
iridocyclitis risk. LDSC highlighted the heritability of certain metabolites, underscoring genetic influences on their levels. Notably, tryptophan, proline, theobromine, and 7-methylxanthine emerged as risk factors, while 3,4-dihydroxybutyrate appeared protective. These findings enhance our understanding of the metabolic interactions in
iridocyclitis, offering insights for diagnosis, unraveling pathophysiological mechanisms, and informing potential avenues for prevention and personalized treatment.