Abstract：
BACKGROUND: Microscopic colitis (MC) is an inflammatory disorder of the colon. To date, the relationship between inflammatory eye diseases and MC is unclear.
OBJECTIVE: To assess whether inflammatory eye disease (iridocyclitis and episcleritis) is a risk factor for MC.
METHODS: We conducted a nationwide matched case control study in Sweden leveraging the ESPRESSO-study (a Swedish database containing data on all biopsies from the gastrointestinal tract from 1965 to 2017). In total, we identified 14,338 patients with biopsy-verified MC (diagnosed from 1981 to 2017). Patients with MC were matched (by age, sex, county and year of birth) with 68,753 controls from the general population and the occurrence of preceding inflammatory eye diseases (defined as diagnosis of episcleritis or iridocyclitis) in the two groups was compared. Multivariable adjusted odds ratios (aORs) were calculated using conditional logistic regression conditioned on the matching variables.
RESULTS: A majority of patients with MC were women (71.9%) and the median age at MC diagnosis was 63.3 years (interquartile range (IQR) = 50.7-72.6). Some 225 (1.6%) MC patients had an earlier record of inflammatory eye disease compared with 614 (0.9%) in controls. These figures corresponded to an aOR of 1.77 (95% CI = 1.52-2.07) for inflammatory eye diseases in patients with MC. Compared to siblings, the aOR for previous inflammatory eye diseases in MC was 1.52 (95% CI = 1.17-1.98) and patients treated with budesonide, as a proxy for clinically significant disease, had a somewhat higher aOR for previous inflammatory eye diseases.
CONCLUSIONS: Inflammatory eye diseases are more common in patients subsequently being diagnosed with MC. Our findings highlight that these conditions may have shared causes and inflammatory pathways and are of clinical interest to gastroenterologists, ophthalmologists and general practitioners.
OBJECTIVE: To assess whether inflammatory eye disease (iridocyclitis and episcleritis) is a risk factor for MC.
METHODS: We conducted a nationwide matched case control study in Sweden leveraging the ESPRESSO-study (a Swedish database containing data on all biopsies from the gastrointestinal tract from 1965 to 2017). In total, we identified 14,338 patients with biopsy-verified MC (diagnosed from 1981 to 2017). Patients with MC were matched (by age, sex, county and year of birth) with 68,753 controls from the general population and the occurrence of preceding inflammatory eye diseases (defined as diagnosis of episcleritis or iridocyclitis) in the two groups was compared. Multivariable adjusted odds ratios (aORs) were calculated using conditional logistic regression conditioned on the matching variables.
RESULTS: A majority of patients with MC were women (71.9%) and the median age at MC diagnosis was 63.3 years (interquartile range (IQR) = 50.7-72.6). Some 225 (1.6%) MC patients had an earlier record of inflammatory eye disease compared with 614 (0.9%) in controls. These figures corresponded to an aOR of 1.77 (95% CI = 1.52-2.07) for inflammatory eye diseases in patients with MC. Compared to siblings, the aOR for previous inflammatory eye diseases in MC was 1.52 (95% CI = 1.17-1.98) and patients treated with budesonide, as a proxy for clinically significant disease, had a somewhat higher aOR for previous inflammatory eye diseases.
CONCLUSIONS: Inflammatory eye diseases are more common in patients subsequently being diagnosed with MC. Our findings highlight that these conditions may have shared causes and inflammatory pathways and are of clinical interest to gastroenterologists, ophthalmologists and general practitioners.
摘要：
背景：显微镜结肠炎（MC）是结肠的一种炎症性疾病。迄今为止,炎症性眼病与MC之间的关系尚不清楚。
目的：评估炎症性眼病（虹膜睫状体炎和上巩膜炎）是否是MC的危险因素。
方法：我们利用ESPRESSO研究（瑞典数据库，包含1965年至2017年来自胃肠道的所有活检数据）在瑞典进行了一项全国匹配的病例对照研究。总的来说,我们确定了14,338例活检证实的MC患者(1981年至2017年诊断).MC患者进行匹配（按年龄，性别,县和出生年份）与普通人群中的68,753名对照，并比较了两组中先前的炎症性眼病（定义为上巩膜炎或虹膜睫状体炎的诊断）的发生情况。使用条件逻辑回归以匹配变量为条件计算多变量调整比值比（aOR）。
结果：大多数MC患者为女性（71.9%），诊断为MC的中位年龄为63.3岁（四分位距（IQR）=50.7-72.6）。与对照组的614例（0.9％）相比，约225例（1.6％）MC患者的炎症性眼病记录较早。这些数字对应于MC患者的炎性眼病的aOR为1.77（95％CI=1.52-2.07）。与兄弟姐妹相比，MC中既往炎症性眼病的aOR为1.52（95％CI=1.17-1.98），用布地奈德治疗的患者，作为临床重大疾病的代表，对以前的炎症性眼病有较高的aOR。
结论：炎症性眼病在随后被诊断为MC的患者中更为常见。我们的发现强调，这些疾病可能具有共同的原因和炎症途径，并且对胃肠病学家具有临床意义。眼科医生和全科医生。
目的：评估炎症性眼病（虹膜睫状体炎和上巩膜炎）是否是MC的危险因素。
方法：我们利用ESPRESSO研究（瑞典数据库，包含1965年至2017年来自胃肠道的所有活检数据）在瑞典进行了一项全国匹配的病例对照研究。总的来说,我们确定了14,338例活检证实的MC患者(1981年至2017年诊断).MC患者进行匹配（按年龄，性别,县和出生年份）与普通人群中的68,753名对照，并比较了两组中先前的炎症性眼病（定义为上巩膜炎或虹膜睫状体炎的诊断）的发生情况。使用条件逻辑回归以匹配变量为条件计算多变量调整比值比（aOR）。
结果：大多数MC患者为女性（71.9%），诊断为MC的中位年龄为63.3岁（四分位距（IQR）=50.7-72.6）。与对照组的614例（0.9％）相比，约225例（1.6％）MC患者的炎症性眼病记录较早。这些数字对应于MC患者的炎性眼病的aOR为1.77（95％CI=1.52-2.07）。与兄弟姐妹相比，MC中既往炎症性眼病的aOR为1.52（95％CI=1.17-1.98），用布地奈德治疗的患者，作为临床重大疾病的代表，对以前的炎症性眼病有较高的aOR。
结论：炎症性眼病在随后被诊断为MC的患者中更为常见。我们的发现强调，这些疾病可能具有共同的原因和炎症途径，并且对胃肠病学家具有临床意义。眼科医生和全科医生。
