METHODS: Seventy-six adult heavy drinkers completed a 7-min resting-state functional MRI scan during visual fixation. Linear regression models tested if connectivity in the three target networks was associated with past 12-month AUD symptoms and number of heavy drinking days in the past 30 days. Exploratory analyses examined correlations between connectivity clusters and impulsivity and psychopathology measures.
RESULTS: Functional connectivity within the CEN network (right and left lateral prefrontal cortex [LPFC] seeds co-activating with 13 and 15 clusters, respectively) was significantly associated with AUD symptoms (right LPFC: β = .337, p-FDR = .016; left LPFC: β = .291, p-FDR = .028) but not heavy drinking (p-FDR > .749). Post-hoc tests revealed six clusters co-activating with the CEN network were associated with AUD symptoms-right middle frontal gyrus, right inferior parietal gyrus, left middle temporal gyrus, and left and right cerebellum. Neither the default mode nor the salience network was significantly associated with alcohol variables. Connectivity in the left LPFC was correlated with monetary delay discounting (r = .25, p = .03).
CONCLUSIONS: These findings support previous associations between connectivity within the CEN network and AUD severity, providing additional specificity to the relevance of the triple network model to AUD.
方法:76名成年重度饮酒者在视觉固定过程中完成了7分钟的静息状态功能MRI扫描。线性回归模型测试了三个目标网络中的连通性是否与过去12个月的AUD症状和过去30天内大量饮酒天数相关。探索性分析检查了连通性簇与冲动性和心理病理学措施之间的相关性。
结果:CEN网络内的功能连接(左右外侧前额叶皮层[LPFC]种子与13和15簇共同激活,分别)与AUD症状显着相关(右LPFC:β=.337,p-FDR=.016;左LPFC:β=.291,p-FDR=.028),但与大量饮酒(p-FDR>.749)无关。事后测试显示,与CEN网络共同激活的六个簇与AUD症状-右额中回有关,右顶叶下回,左颞中回,还有左右小脑.默认模式和显著性网络都与酒精变量没有显着关联。左侧LPFC的连通性与货币延迟贴现相关(r=.25,p=.03)。
结论:这些发现支持CEN网络内的连通性与AUD严重性之间的先前关联,为三重网络模型与AUD的相关性提供额外的特异性。