在这个复杂的糖尿病领域,高胰岛素血症不再仅仅被认为是对胰岛素抵抗的代偿性反应,而是已经发展成为一个不可或缺的特征。这篇全面的综述提供了对当前文献的综合,包括糖尿病并发症中与高胰岛素血症相关的各个方面。高胰岛素血症已被证明不仅仅是一种代偿机制,关键发现表明高胰岛素血症如何影响心血管事件和微血管并发症的发展。此外,认识到高胰岛素血症是一个可改变的因素,糖尿病管理范式转向认知模式,即考虑将生活方式的改变与新的药物疗法和精准医学方法结合使用.这些发现对临床工作具有重要意义,需要仔细了解高胰岛素血症的变化方面,并纳入个性化治疗方案。此外,审查的重点是与公共卫生有关的更大问题,表明预防和早期诊断将有助于减轻并发症的负担。研究意义有利于纵向研究,生物标志物发现,以及对新兴治疗方式的研究;临床实践应采用全球评估,患者教育,和精准医学适应。最后,本综述概述了高胰岛素血症在糖尿病中的潜在过程及其对健康的总体影响.
In this complex realm of diabetes,
hyperinsulinemia is no longer regarded as just a compensatory response to insulin resistance but rather has evolved into an integral feature. This comprehensive review provides a synthesis of the current literature, including various aspects associated with hyperinsulinemia in diabetic complications.
Hyperinsulinemia has been shown to be more than just a compensatory mechanism, and the key findings demonstrate how hyperinsulinism affects the development of cardiovascular events as well as microvascular complications. Additionally, recognizing
hyperinsulinemia as a modifiable factor, the diabetes management paradigm shifts towards cognitive ones that consider the use of lifestyle modifications in combination with newer pharmacotherapies and precision medicine approaches. These findings have crucial implications for the clinical work, requiring a careful appreciation of
hyperinsulinemia\'s changing aspects as well as incorporation in personalized treatment protocol. In addition, the review focuses on bigger issues related to public health, showing that prevention and early diagnosis will help reduce the burden of complications. Research implications favor longitudinal studies, biomarker discovery, and the study of emerging treatment modalities; clinical practice should adopt global evaluations, patient education, and precision medicine adaptation. Finally, this critical review provides an overview of the underlying processes of
hyperinsulinemia in diabetes and its overall health effects.