PDF(Pubmed)
Abstract：
Polycystic ovary syndrome (PCOS) is a leading cause of infertility, with an estimated worldwide prevalence between 5% and 15%. We conducted a case-control study with 121 PCOS patients and 155 controls to assess the association between coffee intake and the presence of having a diagnosis of PCOS in women in Murcia, Spain. The PCOS diagnosis was determined following Rotterdam criteria (the presence of two of the following three conditions: hyperandrogenism, oligo-anovulation, and/or polycystic ovarian morphology). Coffee consumption was assessed using a validated food frequency questionnaire. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multiple logistic regression. Coffee consumption was categorized into never, less than one cup per day, one cup per day, and two or more cups per day. We found a significant inverse linear trend: the higher the coffee consumption, the lower the probability of having PCOS in multivariable analysis (p-trend = 0.034). Women who presented with PCOS were less likely to drink one cup of coffee compared to those who had never drunk coffee (OR = 0.313, 95% CI: 0.141-0.69). The consumption of at least one cup of coffee per day may be associated with a decrease in PCOS symptoms.
摘要：
多囊卵巢综合征（PCOS）是不孕的主要原因，估计全球患病率在5%至15%之间。我们对121名PCOS患者和155名对照进行了病例对照研究，以评估穆尔西亚女性咖啡摄入量与PCOS诊断之间的关系。西班牙。根据鹿特丹标准确定PCOS诊断（存在以下三种情况中的两种：高雄激素血症，低聚无排卵,和/或多囊卵巢形态）。使用经过验证的食物频率问卷评估咖啡消耗。使用多元逻辑回归估计调整后的比值比（ORs）和95％置信区间（CIs）。咖啡消费被归类为从不，每天不到一杯，每天一杯,每天两杯或更多杯。我们发现了一个显著的反线性趋势:咖啡消费量越高，多变量分析中PCOS的概率越低(p趋势=0.034).与从未喝咖啡的女性相比，患有PCOS的女性喝一杯咖啡的可能性较小（OR=0.313，95％CI：0.141-0.69）。每天至少一杯咖啡的消耗可能与PCOS症状的减少有关。
