PDF(Pubmed)
Abstract：
Unfortunately, cardiovascular diseases and cancers are still the leading causes of death in developed and developing countries despite the considerable progress made in the prevention and treatment of diseases. Maybe we missed something? Insulin resistance (IR) with associated hyperinsulinemia (Hypein) is a silent pandemic whose prevalence is continually growing in developed and developing countries, now exceeding 51% of the general population. IR/Hypein, despite the vast scientific literature supporting its adverse action on the development of type 2 diabetes, cardiovascular alterations, tumors, neurological disorders, and cellular senescence, is not yet considered an independent risk factor and, therefore, is not screened in the general population and adequately treated. There are now numerous substances, drugs, and natural substances that, in association with the correction of a wrong lifestyle, can help to reduce IR/Hypein. We are convinced that the time has come to implement a prevention plan against this critical risk factor. Therefore, this manuscript aims to highlight IR/Hypein as an independent risk factor for type 2 diabetes, cardiovascular diseases, cancers, cellular senescence, and neuropsychiatric disorders, supporting our conviction with the available scientific literature on the topic.
摘要：
不幸的是,尽管在预防和治疗疾病方面取得了相当大的进展，但心血管疾病和癌症仍然是发达国家和发展中国家死亡的主要原因。胰岛素抵抗（IR）与相关的高胰岛素血症（Hypein）是一种无声的大流行，其患病率在发达国家和发展中国家都在不断增长，现在超过了总人口的51%。IR/Hypein,尽管大量的科学文献支持其对2型糖尿病的发展的不利作用，心血管改变,肿瘤，神经系统疾病,和细胞衰老，尚未被认为是独立的风险因素，因此,没有在普通人群中进行筛查，也没有得到充分的治疗。现在有很多物质，毒品,和天然物质，与错误生活方式的纠正有关，可以帮助减少IR/Hypein。我们相信，现在是针对这一关键风险因素实施预防计划的时候了。因此,本手稿旨在强调IR/Hypein是2型糖尿病的独立危险因素，心血管疾病,癌症,细胞衰老,和神经精神疾病，通过有关该主题的现有科学文献来支持我们的信念。
