■INTERGROWTH-21st早产后生长标准(IPPGS)已越来越多地用于评估全球早产儿的生长。然而,IPPGS应用于特定早产人群的有效性仍存在争议.这项回顾性队列研究旨在为中国北方的早产队列制定参考生长图,并将其与IPPGS进行比较。
■从2011年1月1日至2021年2月28日出生在山东第一医科大学第一附属医院的早产队列(N=2,011)中,对1,827名健康早产儿进行了随访。使用广义加性模型进行位置,规模,和形状方法,5,539组纵向数据用于构建长度的百分位图和Z评分图,体重,PMA40-64周时的头围(HC)。Z-长度分数,体重,和HC(LAZ,WAZ,使用IPPGS计算64周前的HCZ)。早产儿和IPPGS之间第50百分位数值的差异(dLength,dWeight,和dHC)进行了计算。Z分数被分配到六个PMA集群:40-44、44-48、48-52、52-56、56-60和60-64周,用于性别之间的比较。
■对于符合条件的婴儿,出生时的平均PMA和体重为33.93周和2.3公斤,分别。孩子们,晚期早产儿,双胞胎,纯母乳喂养的婴儿占55.8、70.6、27.8和45.9%,分别。与IPPGS相比,早产儿更长,更重,特别是对于女孩的dLength(范围,2.19-2.97厘米),这几乎跨越了IPPGS的第50和第90百分位数。两性的dHC倾向于用PMA缩小。平均LAZ,WAZ,在所有PMA集群中,男女HCZ均>0,尤其是LAZ和WAZ(相对于IPPGS约1.0),表明在40-64周时水平高于IPPGS。女孩在每个PMA集群都有更大的LAZ,更大的WAZ在40-44周,56周后HCZ低于男孩。HCZ与PMA一起下降。
■在PMA的40-64周时,该早产队列的出生后生长明显高于IPPGS,具有性别差异。
UNASSIGNED: The INTERGROWTH-21st preterm postnatal growth standards (IPPGS) have increasingly been used to evaluate the growth of preterm infants worldwide. However, the validity of IPPGS\'s application to specific preterm populations remains controversial. This retrospective cohort study aimed to formulate reference growth charts for a preterm cohort in northern China and compare them to the IPPGS.
UNASSIGNED: A total of 1,827 healthy preterm infants with follow-up visits before 70 weeks of postmenstrual age (PMA) were retrospectively sampled from a preterm cohort (N = 2,011) born between 1 January 2011 and 28 February 2021, at the First Affiliated Hospital of Shandong First Medical University. Using the Generalized Additive Models for Location, Scale, and Shape method, 5,539 sets of longitudinal data were used to construct percentile and Z-score charts of length, weight, and head circumference (HC) at 40-64 weeks of PMA. Z-scores of length, weight, and HC (LAZ, WAZ, and HCZ) before 64 weeks were calculated using the IPPGS. Differences in the 50th percentile values between preterm infants and IPPGS (dLength, dWeight, and dHC) were calculated. Z-scores were assigned to six PMA clusters: 40-44, 44-48, 48-52, 52-56, 56-60, and 60-64 weeks for comparison between sexes.
UNASSIGNED: For eligible infants, the mean PMA and weight at birth were 33.93 weeks and 2.3 kg, respectively. Boys, late preterm infants, twins, and infants with exclusively breastfeeding accounted for 55.8, 70.6, 27.8, and 45.9%, respectively. Compared to IPPGS, preterm infants were longer and heavier, especially for dLength in girls (range, 2.19-2.97 cm), which almost spanned the 50th and 90th percentiles of IPPGS. The dHC tended to narrow with PMA for both sexes. The mean LAZ, WAZ, and HCZ of both sexes at all PMA clusters were >0, especially for LAZ and WAZ (about 1.0 relative to IPPGS), indicating higher levels than the IPPGS at 40-64 weeks. Girls had larger LAZ at each PMA cluster, larger WAZ at 40-44 weeks, and lower HCZ after 56 weeks than boys. HCZ declined with PMA for both sexes.
UNASSIGNED: Postnatal growth of this preterm cohort was considerably higher than that of the IPPGS at 40-64 weeks of PMA with sex differences.