目的:使用非线性,用82Rb测量心肌血流量(MBF)最小二乘计算机建模。研究目的是探索Gjedde-Patlak-Rutland(GPR)图形分析作为测量MBF的更简单方法的可行性。
方法:患者使用腺苷(n=45)或regadenoson(n=33)进行心肌灌注显像。使用Lortie等人的修改的Crone-Renkin方程从Cedar-SiniQPET软件测量血液82Rb进入肌细胞(K1)的清除率。(K1=[1-0.77×e-B/MBF]×MBF)将K1转换为MBF(ml/min/100ml),其中B(63ml/min/100ml)是心肌通透性-表面积乘积。使用主动脉或左心室腔(LV)测量动脉血82Rb浓度,根据注射后1至3分钟之间获得的数据,通过GPR分析测量了血液82Rb进入心肌(Z)的清除率。作为K1和Z的单位,分别,ml/min/ml细胞内空间和ml/min/ml包括细胞外空间的总组织,心肌细胞外液容积(ECV)为1-[Z/K1]。使用Z/K1(参见结果)修改其索引,Lortie方程更改为Z=(1-0.77×[公式:见正文]e-BZ/MBFZ)*MBFZ,然后从Z计算MBFZ。在GPR分析中,活动从LV到心肌的溢出在图的截距中方便地“下降”。
结果:两种药物几乎相等地增加心肌血流量。静息时ECV为~35ml/100ml,增加到〜40毫升/100毫升后的压力。Z/K1,应力之间的平均值,休息,应力剂和动脉ROI,为0.62,因此BZ取为39(即0.62×63)ml/min/100ml。基于LV,MBFZ(y)与MBF(x)相关:y=0.43x+22ml/min/100ml;r=0.84;n=156)。他们各自的压力/休息比显示中等相关性(r=0.64;n=78)。
结论:GPR分析有望成为测量心肌血流量的有效且分析更简单的技术,which,与从探地雷达分析测得的任何间隙一样,具有ml/min/ml总组织体积的单位,并值得作为极坐标图显示开发。
OBJECTIVE: Myocardial blood flow (MBF) is measured with 82Rb using non-linear, least-squares computerised modelling. The study aim was to explore the feasibility of Gjedde-Patlak-Rutland (GPR) graphical analysis as a simpler method for measuring MBF.
METHODS: Patients had myocardial perfusion imaging using adenosine (n = 45) or regadenoson (n = 33) for stressing. Blood 82Rb clearance into myocytes (K1) was measured from Cedar-Sinai QPET software using the modified Crone-Renkin equation of Lortie et al. (K1 = [1-0.77 × e-B/MBF] × MBF) to convert K1 to MBF (ml/min/100 ml), where B (63 ml/min/100 ml) is myocardial permeability-surface area product. Using aorta or left ventricular cavity (LV) to measure arterial blood 82Rb concentration, blood 82Rb clearance into myocardium (Z) was measured from GPR analysis based on data acquired between 1 and 3 min post-injection. As units of K1 and Z are, respectively, ml/min/ml intracellular space and ml/min/ml total tissue including extracellular space, myocardial extracellular fluid volume (ECV) is 1 - [Z/K1]. Using Z/K1 (see Results) to modify its index, the Lortie equation was changed to Z = (1-0.77 × [Formula: see text]e-BZ/MBFZ)*MBFZ, following which MBFZ was calculated from Z. In GPR analysis, spillover of activity from LV to myocardium conveniently \'drops out\' in the intercept of the plot.
RESULTS: Both agents increased myocardial blood flow almost equally. ECV was ~ 35 ml/100 ml at rest, increasing to ~ 40 ml/100 ml after stress. Z/K1, averaged between stress, rest, stressing agents and arterial ROI, was 0.62, so BZ was taken as 39 (i.e. 0.62 × 63) ml/min/100 ml. Based on LV, MBFZ (y) correlated with MBF (x): y = 0.43x + 22 ml/min/100 ml; r = 0.84; n = 156). Their respective stress/rest ratios showed a moderate correlation (r = 0.64; n = 78).
CONCLUSIONS: GPR analysis offers promise as a valid and analytically simpler technique for measuring myocardial blood flow, which, as with any clearance measured from GPR analysis, has units of ml/min/ml total tissue volume, and merits development as a polar map display.