Abstract：
Objective.This study aims to address the issue of long scan durations required by traditional graphical analysis methods, such as the Logan plot and its variant, the reversible equilibrium (RE) Logan plot, for dynamic PET imaging of tracer kinetics.Approach.We propose a relative RE Logan model that builds on the principles of the Logan plot and its variant to significantly reduce scan time without compromising the accuracy of tracer kinetics analysis. The model is supported by theoretical evidence and experimental validations, including two computer simulations and one clinical data analysis.Main results.The proposed model demonstrates a significant linear relationship between the variablexand the slopeDVTof the RE Logan plot, and the variablex\' and the slopeDVT\'of the relative RE Logan plot. The Pearson correlation coefficients (r) of the linear fitting of thex\' to thexequal 0.9849 in the simulated data and 0.9912 in the clinical data. Similarly, thervalues for the linear fitting ofDVT\'toDVTequal 0.9989 and 0.9988 in the simulated data, and 0.9954 in the clinical data.Significance.These results demonstrate the model\'s capability to maintain strong linear relationships and produce parametric images comparable to the traditional RE Logan plot, but with the considerable advantage of shorter scan durations. This innovation holds significant potential for enhancing the efficiency and feasibility of PET imaging in clinical settings.
摘要：
目的：本研究旨在解决传统图形分析方法所需的长扫描持续时间的问题，比如洛根图及其变体，可逆平衡(RE)洛根图，用于示踪动力学的动态PET成像。＆＃xD;方法：我们提出了一个相对的RELogan模型，该模型建立在Logan图及其变体的原理上，以显着减少扫描时间，而不会损害示踪剂动力学分析的准确性。该模型得到了理论证据和实验验证的支持，包括两个计算机模拟和一个临床数据分析。＆＃xD;主要结果：所提出的模型证明了变量x与RELogan图的斜率DV_T之间存在显着的线性关系，以及相对RELogan图的变量x\'和斜率DV_T\'。x\'与x的线性拟合的皮尔逊相关系数(r)等于模拟数据中的0.9849和临床数据中的0.9912。同样，在模拟数据中，DV_T\'与DV_T线性拟合的r值等于0.9989和0.9988，和0.9954的临床数据。＆＃xD;意义：这些结果证明了该模型具有保持强线性关系并产生与传统RELogan图相当的参数图像的能力，但具有扫描持续时间较短的相当大的优势。这种创新对于提高临床环境中PET成像的效率和可行性具有重要的潜力。
