关于终身胆结石与抑郁症状之间潜在关联的研究有限。这项研究旨在评估胆结石疾病的存在是否与抑郁症状有关。在这项横断面研究中,我们分析了国家健康和营养检查调查(NHANES)2017-2020年3月周期的数据.使用问卷答复评估抑郁症状和胆结石疾病的存在。使用多变量逻辑回归模型计算调整后的比值比(OR),随着年龄的调整,性别,种族,身体质量指数,心血管疾病史,高血压,关节炎,不同模型的肺部疾病。进行亚组和敏感性分析以确保结果的稳定性。这项研究包括6201名20岁及以上的成年人,539(8.7%)出现抑郁症状。在调整了年龄之后,性别,种族,身体质量指数,CVD病史,高血压,关节炎,肺部疾病,抑郁症状可能与终身胆结石相关(OR1.37,95%CI0.91-2.08).当抑郁症状被归类为轻度时,中度,中度严重,严重的,终身胆结石可能与轻度抑郁症状相关(OR1.12,95%CI0.81-1.56),中度抑郁症状(OR1.37,95%CI0.89-2.12),中度重度抑郁症状(OR1.93,95%CI0.93-3.99),和严重的抑郁症状(OR0.67,95%CI0.16-2.88)。作为连续变量,终身胆结石与PHQ-9评分相关(OR0.42,95%CI0.02-0.83).对所有缺失数据进行多次填补后,结果保持稳定。这项横断面研究表明,在美国成年人中,终身胆结石与抑郁症状之间没有显着关联。
Research on the potential association between life-ever
gallstones and depressive symptoms is limited. This study aims to evaluate whether the presence of gallstone disease is associated with depressive symptoms. In this cross-sectional study, we analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 cycles. The presence of depressive symptoms and gallstone disease was assessed using questionnaire responses. Adjusted odds ratios (OR) were calculated using a multivariate logistic regression model, with adjustments made for age, sex, race, body mass index, history of cardiovascular disease, hypertension, arthritis, and pulmonary disease across different models. Subgroup and sensitivity analyses were conducted to ensure the stability of the results. This study included 6201 adults aged 20 years and above, with 539(8.7%) experiencing depressive symptoms. After adjusting for age, sex, race, body mass index, CVD history, hypertension, arthritis, pulmonary disease, depressive symptoms were possibly associated with life-ever
gallstones (OR 1.37, 95% CI 0.91-2.08).When depressive symptoms were categorized as mild, moderate, moderately severe, and severe,life-ever
gallstones was possibly associated with mild depressive symptoms (OR 1.12, 95% CI 0.81-1.56), moderate depressive symptoms (OR 1.37, 95% CI 0.89-2.12), moderately severe depressive symptoms (OR 1.93, 95% CI 0.93-3.99), and severe depressive symptoms (OR 0.67, 95% CI 0.16-2.88).As a continuous variable, life-ever
gallstones was associated with the PHQ-9 score (OR 0.42, 95% CI 0.02-0.83). The results remained stable after multiple imputation for all missing data. This cross-sectional study demonstrates no significant association between life-ever
gallstones and depressive symptoms in US adults.