PDF(Pubmed)
Abstract：
Introduction: Gallstones are one of the most common digestive diseases globally, with an estimated affected population of 15% in the United States. Our aim is to assess the current association between oral health and gallstones, exploring potential mediation factors. Methods: Self-reported gallstones were determined based on medical condition questionnaires. Dental status was assessed by dental professionals and oral health questionnaire. Mediation analysis was conducted for body mass index, blood glucose, triglycerides, and cholesterol, and the percentage of mediation effects was calculated. Results: We included 444 patients with gallstones and 3565 non-gallstone participants from National Health and Nutrition Examination Survey. After fully adjusting for all covariates, the prevalence of gallstones is higher when the number of missing teeth is at T3 compared to T1 (odds ratio [OR]: 1.93, confidence interval [CI]: 1.14 - 3.26, p = 0.02, p-trend = 0.01), and there was an inverted L-shaped association between missing teeth and gallstones, with an inflection point of 17. Bone loss around mouth was also associated with gallstones (OR: 1.78, 95% CI: 1.27 - 2.48, p = 0.002), but not root caries and gum disease. Mediation analysis identified blood glucose as a crucial mediator, with a mediation effect ratio of 4.91%. Conclusions: Appropriate lifestyle interventions for patients with missing teeth may help delay the onset of gallstones, such as healthy dietary habits, trace elements supplementing, and managing weight and blood sugar levels. Further exploration of the relationship between oral health and overall health contributes to disease prevention and comprehensive medical management.
摘要：
简介：胆结石是全球最常见的消化系统疾病之一，在美国，受影响的人口估计为15%。我们的目的是评估口腔健康与胆结石之间的当前关联，探索潜在的调解因素。方法：根据医疗状况问卷确定自我报告的胆结石。通过牙科专业人员和口腔健康问卷评估牙科状况。对体重指数进行中介分析，血糖，甘油三酯，和胆固醇，并计算了调解效果的百分比。结果：我们纳入了来自国家健康和营养调查的444名胆结石患者和3565名非胆结石参与者。在对所有协变量进行完全调整后，与T1相比，T3时的缺齿数量较高（比值比[OR]：1.93，置信区间[CI]：1.14-3.26，p=0.02，p趋势=0.01），牙齿缺失和胆结石之间存在倒L形关联，拐点为17。口腔周围骨丢失也与胆结石相关(OR:1.78,95%CI:1.27-2.48,p=0.002),但不是根面龋齿和牙龈疾病。中介分析确定血糖是一个关键的介质，调解效果率为4.91%。结论：对牙齿缺失患者进行适当的生活方式干预可能有助于延缓胆结石的发病。比如健康的饮食习惯，微量元素补充，控制体重和血糖水平。进一步探索口腔健康与整体健康之间的关系有助于疾病预防和全面医疗管理。
