背景:多发性硬化症(MS)是一种以中枢神经系统(CNS)病变为特征的慢性炎性疾病。尽管MS的病因和发病机制尚不清楚,营养是可能参与发展MS的环境因素之一。目前,没有特定的饮食与MS相关。本研究旨在探讨膳食植物化学指标(DPI)与膳食植物化学指标、膳食酸负荷(DAL),以及发展MS的风险
方法:本病例对照研究是对马什哈德的174名MS患者和171名健康个体进行的,伊朗。使用160项半定量食物频率问卷(FFQ)收集数据。这项研究调查了DPI之间的关联,DAL,MS,考虑到人体测量,饮食摄入量,吸烟习惯,和性爱。DPI,潜在的肾酸负荷(PRAL),和净内源酸产量(NEAP),作为DAL的指标,是根据FFQ计算的。
结果:该研究分析了345名参与者,包括174名(50.4%)MS患者和171名(49.6%)健康个体。参与者的平均年龄为32.45±8.66岁。MS患者的DPI评分明显较低,而MS患者的NEAP和PRAL评分明显高于健康组。NEAP(OR1.001;95%CI0.959-1.044;P=0.974)和PRAL(OR1.019;95%CI0.979-1.061;P=0.356)与MS发生率无相关性。
结论:研究发现,MS患者的吸烟率和肥胖率更高,DPI分数降低,DAL增加。在推荐植物性食物和饮食酸碱平衡评估作为治疗方法之前,还需要进一步的研究。
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions. Although the etiology and pathogenesis of MS remains unclear, nutrition is among the environmental factors that may be involved in developing MS. Currently, no specific diet has been associated with MS. This study aimed to investigate the relationship between the dietary phytochemical index (DPI), dietary acid load (DAL), and the risk of developing MS.
METHODS: This case‒control study was conducted on 174 patients with MS and 171 healthy individuals in Mashhad, Iran. Data were collected using a 160-item semiquantitative food frequency questionnaire (FFQ). The study investigated the association between DPI, DAL, and MS, considering anthropometric measures, dietary intake, smoking habits, and sex. DPI, potential renal acid load (PRAL), and net endogenous acid production (NEAP), as indicators of DAL, were calculated based on the FFQ.
RESULTS: The study analyzed 345 participants, comprising 174 (50.4%) MS patients and 171 (49.6%) healthy individuals. The mean age of the participants was 32.45 ± 8.66 years. The DPI score was significantly lower among MS patients, while the NEAP and PRAL scores were significantly higher among MS patients compared to the healthy group. There was no relationship between NEAP (OR 1.001; 95% CI 0.959-1.044; P = 0.974) and PRAL (OR 1.019; 95% CI 0.979-1.061; P = 0.356) and MS incidence.
CONCLUSIONS: The study found higher smoking and obesity rates in MS patients, with a reduced DPI score and increased DAL. Further studies are needed before recommending plant-based foods and dietary acid-base balance evaluation as therapeutic approach.