■本研究旨在调查社区内2型糖尿病患者中25-羟基维生素D与血清乙酰肝素之间的联系。目的是为临床干预提供基础。
■在2019年11月至2021年7月之间,在山西省东南部的社区卫生服务站连续收集了463名2型糖尿病患者的数据。编制了一般信息和实验室指标,包括血清反前列腺素水平.参与者根据三个血清四氢脂蛋白分位数进行分类,允许比较各组之间的各种因素。分析患者血清中乙酰肝素水平与其他因素的相关性。采用一般的线性模型,研究了25-羟维生素D与血清乙酰肝素水平之间的关系。利用25-羟基维生素D的三个分位数,血清反前列腺素被视为因变量,而25-羟基维生素D作为线性回归分析的自变量。
■随着血清中的反前列腺素增加,年龄逐渐增加,疾病持续时间,SBP,BMI,WC,肌酐,SUA水平(P<0.05)。相反,HbA1c,HDL-C,GFR,25-羟维生素D水平呈逐渐下降趋势(P<0.05)。年龄,25-羟基维生素D,SUA,肌酐,LDL-C是血清天门冬氨酸的独立影响因素。在第一至第三25-羟基维生素D分位数,升高的25-羟维生素D水平与平均血清阿斯普罗素的逐渐降低相关(P<0.05)。
■在社区居住的2型糖尿病患者中,血清冬氨酸水平与25-羟维生素D水平呈负相关。血清反前列腺素水平可能独立地导致25-羟基维生素D水平。
UNASSIGNED: This study aimed to investigate the link between 25-hydroxy vitamin D and serum asprosin in individuals with type 2 diabetes within the community. The goal was to provide a foundation for clinical interventions.
UNASSIGNED: Between November 2019 and July 2021, data from 463 patients with type 2 diabetes were consistently gathered at a community health service station in Southeast Shanxi Province. General information and laboratory metrics were compiled, including serum asprosin levels. The participants were categorized based on three serum asprosin quantiles, allowing for a comparison of various factors among the groups. The correlation between serum asprosin levels and other factors was analyzed. Employing a general linear model, the connection between 25-hydroxy vitamin D and serum asprosin levels was studied. Utilizing three quantiles of 25-hydroxy vitamin D, serum asprosin was treated as the dependent variable, while 25-hydroxy vitamin D served as the independent variable for linear regression analysis.
UNASSIGNED: As serum asprosin increased, there were gradual increments in age, disease duration, SBP, BMI, WC, creatinine, and SUA levels (P<0.05). Conversely, HbA1c, HDL-C, GFR, and 25-hydroxy vitamin D levels exhibited gradual declines (P<0.05). Age, 25-hydroxy vitamin D, SUA, creatinine, and LDL-C emerged as independent influencing factors for serum asprosin. Across the 1st to 3rd 25-hydroxy vitamin D quantiles, elevated 25-hydroxy vitamin D levels correlated with a gradual reduction in mean serum asprosin (P<0.05).
UNASSIGNED: Serum asprosin levels demonstrate an inverse correlation with 25-hydroxy vitamin D levels in community-dwelling individuals with type 2 diabetes. Serum asprosin levels might independently contribute to 25-hydroxy vitamin D levels.