胃肠炎病毒是全世界儿童腹泻的主要病原体。我们提供了2003年至2023年之间发表的三十三(33)项合格研究的数据,这些研究来自首当其冲的非洲国家与病毒相关的腹泻死亡率。随机效应荟萃分析与比例,子组,并采用荟萃回归分析。总的来说,在所有初级保健就诊和住院中,估计合并患病率为31.0%(95%CI24.0-39.0)的轮状病毒占主导地位,其次是诺如病毒,腺病毒,sapovirus,星状病毒,合并流行率估计为15.0%(95%CI12.0-20.0),10%(95%CI6-15),4.0%(95%CI2.0-6.0),4%(95%CI3-6),和2.3%(95%CI1-3),分别。轮状病毒的主要基因型是G1P[8](39%),其次是G3P[8](11.7%),G9P[8](8.7%),和G2P[4](7.1%);尽管,还观察到不寻常的基因型,包括G3P[6](2.7%),G8P[6](1.7%),G1P[6](1.5%),G10P[8](0.9%),G8P[4](0.5%),和G4P[8](0.4%)。基因组II诺如病毒在基因组I相关感染中占主导地位(84.6%,613/725vs14.9%,108/725),GII.4(79.3%)是最普遍的循环基因型。总之,本综述显示,轮状病毒仍然是非洲5岁以下儿童病毒性腹泻的主要驱动因素,需要就医和住院治疗.因此,为了有效控制和管理病例,需要改进该地区的轮状病毒疫苗接种和监测,以确定轮状病毒的残留负担和其他肠道病毒的演变趋势。
Gastroenteritis viruses are the leading etiologic agents of diarrhea in children worldwide. We present data from thirty-three (33) eligible studies published between 2003 and 2023 from African countries bearing the brunt of the virus-associated diarrheal mortality. Random effects meta-analysis with proportion, subgroups, and meta-regression analyses were employed. Overall, rotavirus with estimated pooled prevalence of 31.0 % (95 % CI 24.0-39.0) predominated in all primary care visits and hospitalizations, followed by norovirus, adenovirus, sapovirus, astrovirus, and aichivirus with pooled prevalence estimated at 15.0 % (95 % CI 12.0-20.0), 10 % (95 % CI 6-15), 4.0 % (95 % CI 2.0-6.0), 4 % (95 % CI 3-6), and 2.3 % (95 % CI 1-3), respectively. Predominant rotavirus genotype was G1P[8] (39 %), followed by G3P[8] (11.7 %), G9P[8] (8.7 %), and G2P[4] (7.1 %); although, unusual genotypes were also observed, including G3P[6] (2.7 %), G8P[6] (1.7 %), G1P[6] (1.5 %), G10P[8] (0.9 %), G8P[4] (0.5 %), and G4P[8] (0.4 %). The genogroup II norovirus predominated over the genogroup I-associated infections (84.6 %, 613/725 vs 14.9 %, 108/725), with the GII.4 (79.3 %) being the most prevalent circulating genotype. In conclusion, this review showed that rotavirus remains the leading driver of viral diarrhea requiring health care visits and hospitalization among under-five years children in Africa. Thus, improved rotavirus vaccination in the region and surveillance to determine the residual burden of rotavirus and the evolving trend of other enteric viruses are needed for effective control and management of cases.