皮肤红斑狼疮的一种亚型,称为红斑狼疮肿瘤(LET),其特征在于暴露于阳光的区域,通常表现出荨麻疹样丘疹和斑块。对于LET,抗疟药-特别是羟氯喹(HCQ)的全身治疗是一线治疗.尽管这些药物的安全性似乎很高,文献中关于副作用的报道很少,包括溶血性贫血,视网膜毒性,斑丘疹,胃肠紊乱,皮肤或粘膜的蓝灰色变色。这里,我们报告了一个46岁的LET吸烟者的独特例子,HCQ处理后,出现了全身性肌病.
A subtype of cutaneous lupus erythematosus known as lupus erythematosus tumidus (LET) is characterized by sun-exposed areas that typically display urticaria-like papules and plaques. For LET, systemic therapy with antimalarials - particularly hydroxychloroquine (HCQ) - is the first line of treatment. Even though the safety profile of these medications appears to be high, there have been very few reports of side effects in the literature, including hemolytic anemia, retinal toxicity, maculopapular rash, gastrointestinal disturbance, and blue-gray discoloration of the skin or mucous membranes. Here, we report a unique instance of a 46-year-old LET smoker who, following HCQ treatment, developed a generalized myopathy.