PDF(Pubmed)
Abstract：
Hydroxychloroquine (HCQ) is a commonly used medication for its immunosuppressive and dermatologic effects. It has known ocular side effects, which include retinopathy, corneal deposits, and choroidal thinning. Herein, we report the first known case of HCQ-induced hyperpigmentation of the sclera. A 75-year-old female presented after 10 months of gradual progression of painless blue-gray discoloration of the bilateral sclera, fingernails, and lower extremities secondary to oral HCQ therapy. Cessation of the drug led to a partial reversal of the hyperpigmentation at 5 months, further supporting HCQ as the causative agent. Hyperpigmentation reactions can be distressing to patients and lead to decreased medication adherence; given the widespread use of HCQ, it is important to increase awareness of this potential drug reaction.
摘要：
羟氯喹（HCQ）是一种常用的药物，具有免疫抑制和皮肤病学作用。它有已知的眼部副作用，其中包括视网膜病变，角膜沉积物,脉络膜变薄。在这里，我们报道了首例已知的HCQ诱导的巩膜色素沉着过度。一名75岁的女性在双侧巩膜无痛蓝灰色变色逐渐进展10个月后出现，手指甲,和下肢继发于口服HCQ治疗。停药导致5个月时色素沉着过度的部分逆转，进一步支持HCQ作为病原体。色素沉着过度反应可能会使患者感到困扰，并导致药物依从性下降；鉴于HCQ的广泛使用，提高对这种潜在药物反应的认识很重要。
