■在一项为期12周的随机对照试验中,使用代谢型框架提供的个性化营养改善了饮食摄入量,与人群水平的饮食建议相比,代谢健康参数和代谢组学概况。本工作的目的是调查干预期间提供的饮食建议的模式以及饮食摄入和代谢和代谢组学概况的变化,以进一步了解代谢型框架的有效性。
■将49名个体随机分为干预组,随后使用四种生物标志物(三酰甘油,HDL-C,总胆固醇,葡萄糖)。这些个体从包含代谢型和个体特征的决策树算法中接受个性化饮食建议。在对数据的二次分析中,通过根据收到的饮食信息对个体进行聚类来确定饮食建议的模式,并比较聚类中饮食摄入量和代谢健康参数的变化。研究了血液临床化学变化与代谢物水平变化之间的相关性。
■确定了两组具有不同饮食建议模式的个体。第1组发送的信息比例最高,以增加豆类和豆类以及牛奶和乳制品的摄入量。第2组传递的信息比例最高,以限制高糖食物的摄入量,高脂肪食物和酒精。干预之后,两种模式都改善了通过替代地中海饮食评分和替代健康饮食指数评估的饮食质量,营养素摄入量,血压,三酰甘油和LDL-C(p≤0.05)。确定了总胆固醇变化之间的几种相关性,LDL-C,三酰基甘油,胰岛素和HOMA-IR以及代谢物水平的变化,主要包括脂质(鞘磷脂,溶血磷脂酰胆碱,甘油磷酸胆碱和脂肪酸肉碱)。
■研究结果表明,代谢型框架有效地个性化并提供饮食建议,以改善饮食质量和代谢健康。
■isrctn.com,标识符ISRCTN15305840。
UNASSIGNED: In a 12-week randomised controlled trial, personalised nutrition delivered using a metabotype framework improved dietary intake, metabolic health parameters and the metabolomic profile compared to population-level dietary advice. The objective of the present work was to investigate the patterns of dietary advice delivered during the intervention and the alterations in dietary intake and metabolic and metabolomic profiles to obtain further insights into the effectiveness of the metabotype framework.
UNASSIGNED: Forty-nine individuals were randomised into the intervention group and subsequently classified into metabotypes using four biomarkers (triacylglycerol, HDL-C, total cholesterol, glucose). These individuals received personalised dietary advice from decision tree algorithms containing metabotypes and individual characteristics. In a secondary analysis of the data, patterns of dietary advice were identified by clustering individuals according to the dietary messages received and clusters were compared for changes in dietary intake and metabolic health parameters. Correlations between changes in blood clinical chemistry and changes in metabolite levels were investigated.
UNASSIGNED: Two clusters of individuals with distinct patterns of dietary advice were identified. Cluster 1 had the highest percentage of messages delivered to increase the intake of beans and pulses and milk and dairy products. Cluster 2 had the highest percentage of messages delivered to limit the intake of foods high in added sugar, high-fat foods and alcohol. Following the intervention, both patterns improved dietary quality assessed by the Alternate Mediterranean Diet Score and the Alternative Healthy Eating Index, nutrient intakes, blood pressure, triacylglycerol and LDL-C (p ≤ 0.05). Several correlations were identified between changes in total cholesterol, LDL-C, triacylglycerol, insulin and HOMA-IR and changes in metabolites levels, including mostly lipids (sphingomyelins, lysophosphatidylcholines, glycerophosphocholines and fatty acid carnitines).
UNASSIGNED: The findings indicate that the metabotype framework effectively personalises and delivers dietary advice to improve dietary quality and metabolic health.
UNASSIGNED: isrctn.com, identifier ISRCTN15305840.