PDF(Pubmed)
Abstract：
BACKGROUND: Hyperemesis gravidarum (HG) affects about 2% of pregnancies and is at the severe end of the spectrum of nausea and vomiting of pregnancy. HG causes severe maternal distress and results in adverse pregnancy outcomes long after the condition may have dissipated. Although dietary advice is a common tool in management, trial evidence to base the advice on is lacking.
METHODS: A randomized trial was conducted in a university hospital from May 2019 to December 2020. 128 women at their discharge following hospitalization for HG were randomized: 64 to watermelon and 64 to control arm. Women were randomized to consume watermelon and to heed the advice leaflet or to heed the dietary advice leaflet alone. A personal weighing scale and a weighing protocol were provided to all participants to take home. Primary outcomes were bodyweight change at the end of week 1 and week 2 compared to hospital discharge.
RESULTS: Weight change (kg) at end of week 1, median[interquartile range] -0.05[-0.775 to + 0.50] vs. -0.5[-1.4 to + 0.1] P = 0.014 and to the end of week 2, + 0.25[-0.65 to + 0.975] vs. -0.5[-1.3 to + 0.2] P = 0.001 for watermelon and control arms respectively. After two weeks, HG symptoms assessed by PUQE-24 (Pregnancy-Unique Quantification of Emesis and Nausea over 24 h), appetite assessed by SNAQ (Simplified Nutritional Appetite Questionnaire), wellbeing and satisfaction with allocated intervention NRS (0-10 numerical rating scale) scores, and recommendation of allocated intervention to a friend rate were all significantly better in the watermelon arm. However, rehospitalization for HG and antiemetic usage were not significantly different.
CONCLUSIONS: Adding watermelon to the diet after hospital discharge for HG improves bodyweight, HG symptoms, appetite, wellbeing and satisfaction.
BACKGROUND: This study was registered with the center\'s Medical Ethics Committee (on 21/05/2019; reference number 2019327-7262) and the ISRCTN on 24/05/2019 with trial identification number: ISRCTN96125404 . First participant was recruited on 31/05/ 2019.
METHODS: A randomized trial was conducted in a university hospital from May 2019 to December 2020. 128 women at their discharge following hospitalization for HG were randomized: 64 to watermelon and 64 to control arm. Women were randomized to consume watermelon and to heed the advice leaflet or to heed the dietary advice leaflet alone. A personal weighing scale and a weighing protocol were provided to all participants to take home. Primary outcomes were bodyweight change at the end of week 1 and week 2 compared to hospital discharge.
RESULTS: Weight change (kg) at end of week 1, median[interquartile range] -0.05[-0.775 to + 0.50] vs. -0.5[-1.4 to + 0.1] P = 0.014 and to the end of week 2, + 0.25[-0.65 to + 0.975] vs. -0.5[-1.3 to + 0.2] P = 0.001 for watermelon and control arms respectively. After two weeks, HG symptoms assessed by PUQE-24 (Pregnancy-Unique Quantification of Emesis and Nausea over 24 h), appetite assessed by SNAQ (Simplified Nutritional Appetite Questionnaire), wellbeing and satisfaction with allocated intervention NRS (0-10 numerical rating scale) scores, and recommendation of allocated intervention to a friend rate were all significantly better in the watermelon arm. However, rehospitalization for HG and antiemetic usage were not significantly different.
CONCLUSIONS: Adding watermelon to the diet after hospital discharge for HG improves bodyweight, HG symptoms, appetite, wellbeing and satisfaction.
BACKGROUND: This study was registered with the center\'s Medical Ethics Committee (on 21/05/2019; reference number 2019327-7262) and the ISRCTN on 24/05/2019 with trial identification number: ISRCTN96125404 . First participant was recruited on 31/05/ 2019.
摘要：
背景：妊娠剧吐（HG）影响约2％的妊娠，并且处于妊娠恶心和呕吐的严重终点。HG会导致严重的产妇困扰，并在病情消失后很长时间内导致不良的妊娠结局。尽管饮食建议是管理中常见的工具，缺乏提供建议的试验证据。
方法：一项随机试验于2019年5月至2020年12月在一所大学医院进行。因HG住院后出院的128名妇女被随机分配：64名西瓜和64名对照组。妇女被随机分配食用西瓜，并听取建议单或仅听取饮食建议单。向所有参与者提供个人称重秤和称重方案以带回家。主要结果是与出院相比，第1周和第2周结束时的体重变化。
结果：第1周结束时的体重变化（kg），中位数[四分位数范围]-0.05[-0.775至+0.50]与-0.5[-1.4至+0.1]P=0.014，至第2周结束，+0.25[-0.65至+0.975]与西瓜和对照臂分别为-0.5[-1.3至+0.2]P=0.001。两周后,通过PUQE-24（妊娠-24小时内呕吐和恶心的独特定量）评估的HG症状，通过SNAQ（简化营养食欲问卷）评估食欲，幸福感和对分配的干预NRS(0-10数字评定量表)得分的满意度，在西瓜臂中，对朋友率进行分配干预的建议都明显更好。然而,HG的再次住院和止吐的使用没有显着差异。
结论：HG出院后在饮食中添加西瓜可改善体重，HG症状,食欲,幸福和满足感。
背景：本研究在中心医学伦理委员会（2019年5月21日；参考号2019327-7262）和2019年5月24日的ISRCTN注册，试验标识号：ISRCTN96125404。第一位参与者于2019年5月31日招募。
方法：一项随机试验于2019年5月至2020年12月在一所大学医院进行。因HG住院后出院的128名妇女被随机分配：64名西瓜和64名对照组。妇女被随机分配食用西瓜，并听取建议单或仅听取饮食建议单。向所有参与者提供个人称重秤和称重方案以带回家。主要结果是与出院相比，第1周和第2周结束时的体重变化。
结果：第1周结束时的体重变化（kg），中位数[四分位数范围]-0.05[-0.775至+0.50]与-0.5[-1.4至+0.1]P=0.014，至第2周结束，+0.25[-0.65至+0.975]与西瓜和对照臂分别为-0.5[-1.3至+0.2]P=0.001。两周后,通过PUQE-24（妊娠-24小时内呕吐和恶心的独特定量）评估的HG症状，通过SNAQ（简化营养食欲问卷）评估食欲，幸福感和对分配的干预NRS(0-10数字评定量表)得分的满意度，在西瓜臂中，对朋友率进行分配干预的建议都明显更好。然而,HG的再次住院和止吐的使用没有显着差异。
结论：HG出院后在饮食中添加西瓜可改善体重，HG症状,食欲,幸福和满足感。
背景：本研究在中心医学伦理委员会（2019年5月21日；参考号2019327-7262）和2019年5月24日的ISRCTN注册，试验标识号：ISRCTN96125404。第一位参与者于2019年5月31日招募。
