METHODS: A randomized trial was conducted in a university hospital from May 2019 to December 2020. 128 women at their discharge following hospitalization for HG were randomized: 64 to watermelon and 64 to control arm. Women were randomized to consume watermelon and to heed the advice leaflet or to heed the dietary advice leaflet alone. A personal weighing scale and a weighing protocol were provided to all participants to take home. Primary outcomes were bodyweight change at the end of week 1 and week 2 compared to hospital discharge.
RESULTS: Weight change (kg) at end of week 1, median[interquartile range] -0.05[-0.775 to + 0.50] vs. -0.5[-1.4 to + 0.1] P = 0.014 and to the end of week 2, + 0.25[-0.65 to + 0.975] vs. -0.5[-1.3 to + 0.2] P = 0.001 for watermelon and control arms respectively. After two weeks, HG symptoms assessed by PUQE-24 (Pregnancy-Unique Quantification of Emesis and Nausea over 24 h), appetite assessed by SNAQ (Simplified Nutritional Appetite Questionnaire), wellbeing and satisfaction with allocated intervention NRS (0-10 numerical rating scale) scores, and recommendation of allocated intervention to a friend rate were all significantly better in the watermelon arm. However, rehospitalization for HG and antiemetic usage were not significantly different.
CONCLUSIONS: Adding watermelon to the diet after hospital discharge for HG improves bodyweight, HG symptoms, appetite, wellbeing and satisfaction.
BACKGROUND: This study was registered with the center\'s Medical Ethics Committee (on 21/05/2019; reference number 2019327-7262) and the ISRCTN on 24/05/2019 with trial identification number: ISRCTN96125404 . First participant was recruited on 31/05/ 2019.
方法:一项随机试验于2019年5月至2020年12月在一所大学医院进行。因HG住院后出院的128名妇女被随机分配:64名西瓜和64名对照组。妇女被随机分配食用西瓜,并听取建议单或仅听取饮食建议单。向所有参与者提供个人称重秤和称重方案以带回家。主要结果是与出院相比,第1周和第2周结束时的体重变化。
结果:第1周结束时的体重变化(kg),中位数[四分位数范围]-0.05[-0.775至+0.50]与-0.5[-1.4至+0.1]P=0.014,至第2周结束,+0.25[-0.65至+0.975]与西瓜和对照臂分别为-0.5[-1.3至+0.2]P=0.001。两周后,通过PUQE-24(妊娠-24小时内呕吐和恶心的独特定量)评估的HG症状,通过SNAQ(简化营养食欲问卷)评估食欲,幸福感和对分配的干预NRS(0-10数字评定量表)得分的满意度,在西瓜臂中,对朋友率进行分配干预的建议都明显更好。然而,HG的再次住院和止吐的使用没有显着差异。
结论:HG出院后在饮食中添加西瓜可改善体重,HG症状,食欲,幸福和满足感。
背景:本研究在中心医学伦理委员会(2019年5月21日;参考号2019327-7262)和2019年5月24日的ISRCTN注册,试验标识号:ISRCTN96125404。第一位参与者于2019年5月31日招募。