目的:在本研究中,从环氧树脂(ER)开发的生物活性牙科植入物(BDI),羟基磷灰石(HA),和姜黄素纳米颗粒(CUNP)。
方法:制备的BDI使用其物理化学,机械,抗菌,生物活性,和生物相容性研究。将BDI浸入受激体液(SBF)溶液中后,观察到HA矿化晶体层的扫描电子显微镜(SEM)形态。
结果:BDI的机械性能表现出拉伸强度(250.61±0.43MPa),断裂伸长率(215.66±0.87%),弯曲模量(03.90±0.12GPa),吸水率(05.68±0.15%),和水解吸(06.42±0.14%)。在针对革兰氏阴性(15.33±0.04%)和革兰氏阳性(15.98±0.07%)细菌的优异抑制区中观察到BDI的抗微生物活性。使用MTT(3-[4,5-二甲基噻唑-2-基]-2,5二苯基四唑溴化物)测定法分析了BDI对成骨细胞系(MG-63)的生物相容性研究。与对照(仅ER)样品相比,在BDI中观察到85%的活细胞存在的结果。
结论:根据研究结果,BDI可用于生物材料应用,特别是牙齿种植。
OBJECTIVE: In this study, the developed bioactive dental implant (BDI) from epoxy resin (ER), hydroxyapatite (HA), and curcumin nanoparticles (CUNPs).
METHODS: The prepared BDI were characterized using their physicochemical, mechanical, antimicrobial, bioactive, and biocompatibility study. The scanning electron microscopy (SEM) morphology of the BDI was observed HA mineralized crystal layer after being immersed in the stimulated body fluids (SBF) solution.
RESULTS: The mechanical properties of the BDI exhibited tensile strength (250.61 ± 0.43 MPa), elongation at break (215.66 ± 0.87%), flexural modulus (03.90 ± 0.12 GPa), water absorption (05.68 ± 0.15%), and water desorption (06.42 ± 0.14%). The antimicrobial activity of BDI was observed in excellent zone of inhibition against the gram-negative (15.33 ± 0.04%) and gram- positive (15.98 ± 0.07%) bacteria. The biocompatibility study of BDI on osteoblasts cell line (MG-63) was analyzed using MTT (3-[4, 5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results were observed 85% viable cells present in the BDI compared to the control (only ER) samples.
CONCLUSIONS: Based on the research outcome, the BDI could be used for biomaterials application, particularly tooth dental implantation.