Abstract：
Non-invasive antitumor therapy can treat tumor patients who cannot tolerate surgery or are unsuitable. However, tumor resistance to non-invasive antitumor therapy and cardiotoxicity caused by treatment seriously affect the quality of life and prognosis of patients. As a kind of polyphenol extracted from herbs, curcumin has many pharmacological effects, such as anti-inflammation, antioxidation, antitumor, etc. Curcumin plays the antitumor effect by directly promoting tumor cell death and reducing tumor cells\' invasive ability. Curcumin exerts the therapeutic effect mainly by inhibiting the nuclear factor-κB (NF-κB) signal pathway, inhibiting the production of cyclooxygenase-2 (COX-2), promoting the expression of caspase-9, and directly inducing reactive oxygen species (ROS) production in tumor cells. Curcumin nanoparticles can solve curcumin\'s shortcomings, such as poor water solubility and high metabolic rate, and can be effectively used in antitumor therapy. Curcumin nanoparticles can improve the prognosis and quality of life of tumor patients by using as adjuvants to enhance the sensitivity of tumors to non-invasive therapy and reduce the side effects, especially cardiotoxicity. In this paper, we collect and analyze the literature of relevant databases. It is pointed out that future research on curcumin tends to alleviate the adverse reactions caused by treatment, which is of more significance to tumor patients.
摘要：
非侵入性抗肿瘤治疗可以治疗不能耐受手术或不适合手术的肿瘤患者。然而,非侵袭性抗肿瘤治疗所引起的心脏毒性和肿瘤耐药严重影响患者的生活质量和预后。作为一种从草药中提取的多酚，姜黄素具有多种药理作用,如抗炎，抗氧化，抗肿瘤，等。姜黄素通过直接促进肿瘤细胞死亡和降低肿瘤细胞的侵袭能力发挥抗肿瘤作用。姜黄素主要通过抑制核因子-κB(NF-κB)信号通路发挥治疗作用,抑制环氧合酶-2（COX-2）的产生，促进caspase-9的表达，并直接诱导肿瘤细胞中活性氧（ROS）的产生。姜黄素纳米粒子可以解决姜黄素的缺点,如水溶性差和高代谢率，可有效用于抗肿瘤治疗。姜黄素纳米粒作为佐剂可改善肿瘤患者的预后和生活质量，增强肿瘤对非侵入性治疗的敏感性，减少副作用。尤其是心脏毒性.在本文中,我们收集和分析相关数据库的文献。指出今后对姜黄素的研究倾向于缓解治疗引起的不良反应,这对肿瘤患者更有意义。
