{Reference Type}: Journal Article
{Title}: Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke.
{Author}: Khuwaja G;Moni SS;Alam MF;Makeen HA;Zafar S;Ashafaq M;Alhazmi H;Najmi A;Sayed SF;Shakeel Iqubal SM;
{Journal}: Nanomedicine (Lond)
{Volume}: 19
{Issue}: 12
{Year}: 2024 Apr 25
{Factor}: 6.096
{DOI}: 10.2217/nnm-2024-0008
{Abstract}: Aim: The study was designed to develop and analyze curcumin nanoparticles. Methods: Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity. Results: Curcumin nanoparticles displayed a zeta potential of -55 ± 13.5 mV and an average particle size of 51.40 ± 21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation. Conclusion: Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.<BR>[Box: see text].